2(3H)-Furanone,dihydro-5-phenyl-

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Names

[ CAS No. ]:
1008-76-0

[ Name ]:
2(3H)-Furanone,dihydro-5-phenyl-

[Synonym ]:
MFCD00005398
γ-PHENYL-γ-BUTYROLACTONE
EINECS 213-761-0

Chemical & Physical Properties

[ Density]:
1.155 g/mL at 25 °C(lit.)

[ Boiling Point ]:
306 °C(lit.)

[ Melting Point ]:
36-37 °C(lit.)

[ Molecular Formula ]:
C10H10O2

[ Molecular Weight ]:
162.18500

[ Flash Point ]:
>230 °F

[ Exact Mass ]:
162.06800

[ PSA ]:
26.30000

[ LogP ]:
2.06470

[ Vapour Pressure ]:
0.000793mmHg at 25°C

[ Index of Refraction ]:
1.5415-1.5435

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
LU3690000
CHEMICAL NAME :
2(3H)-Furanone, 4,5-dihydro-5-phenyl-
CAS REGISTRY NUMBER :
1008-76-0
BEILSTEIN REFERENCE NO. :
0125169
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C10-H10-O2
MOLECULAR WEIGHT :
162.20
WISWESSER LINE NOTATION :
T5OVTJ ER

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 18,439,1977

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
LU3690000

[ HS Code ]:
2932209090

Customs

[ HS Code ]: 2932209090

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Pronounced differences in inhibition potency of lactone and non-lactone compounds for mouse and human coumarin 7-hydroxylases (CYP2A5 and CYP2A6).

Xenobiotica 30(1) , 81-92, (2000)

1. The structural requirements for a compound to be a potent inhibitor for mouse CYP2A5 and human CYP2A6 enzymes catalysing coumarin 7-hydroxylase activity have been studied. 2. The IC50 of 28 compoun...


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Related Compounds

  • 2(3H)-Furanone,dihydro-5-phenyl-4-(phenylseleno)
  • 2(3H)-Furanone,dihydro-5-phenyl-3-(phenylsulfinyl)
  • 2(3H)-Furanone,dihydro-5-phenyl-3-(phenylthio)-,trans
  • 2(3H)-Furanone,dihydro-5-phenyl-3,3-bis(phenylmethyl)
  • 2(3H)-Furanone,dihydro-5-phenyl-3-(phenylmethylene)-,(E)
  • 2(3H)-Furanone,dihydro-5-phenyl-3-(1-piperidinyl)-, hydrochloride (1:1)