2(3H)-Furanone,dihydro-5-phenyl-

Names

[ CAS No. ]:
1008-76-0

[ Name ]:
2(3H)-Furanone,dihydro-5-phenyl-

[Synonym ]:
MFCD00005398
γ-PHENYL-γ-BUTYROLACTONE
EINECS 213-761-0

Chemical & Physical Properties

[ Density]:
1.155 g/mL at 25 °C(lit.)

[ Boiling Point ]:
306 °C(lit.)

[ Melting Point ]:
36-37 °C(lit.)

[ Molecular Formula ]:
C₁₀H₁₀O₂

[ Molecular Weight ]:
162.18500

[ Flash Point ]:
>230 °F

[ Exact Mass ]:
162.06800

[ PSA ]:
26.30000

[ LogP ]:
2.06470

[ Vapour Pressure ]:
0.000793mmHg at 25°C

[ Index of Refraction ]:
1.5415-1.5435

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LU3690000

CHEMICAL NAME :: 2(3H)-Furanone, 4,5-dihydro-5-phenyl-

CAS REGISTRY NUMBER :: 1008-76-0

BEILSTEIN REFERENCE NO. :: 0125169

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C10-H10-O2

MOLECULAR WEIGHT :: 162.20

WISWESSER LINE NOTATION :: T5OVTJ ER

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 18,439,1977

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
LU3690000

[ HS Code ]:
2932209090

Customs

[ HS Code ]: 2932209090

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Pronounced differences in inhibition potency of lactone and non-lactone compounds for mouse and human coumarin 7-hydroxylases (CYP2A5 and CYP2A6).

Xenobiotica 30(1) , 81-92, (2000)

1. The structural requirements for a compound to be a potent inhibitor for mouse CYP2A5 and human CYP2A6 enzymes catalysing coumarin 7-hydroxylase activity have been studied. 2. The IC50 of 28 compoun...

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