Olomoucine

Suppliers

Names

[ Name ]:
Olomoucine

[Synonym ]:
OLO
olomoucine
2-{[6-(Benzylamino)-9-methyl-9H-purin-2-yl]amino}ethanol
Ethanol, 2-[[9-methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-
MFCD00189360
Olomoucine,high purity
2-(6-Benzylamino-9-methyl-9H-purin-2-ylamino)-ethanol Olomoucine

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
579.6±60.0 °C at 760 mmHg

[ Melting Point ]:
120-130 °C

[ Molecular Formula ]:
C₁₅H₁₈N₆O

[ Molecular Weight ]:
298.343

[ Flash Point ]:
304.3±32.9 °C

[ Exact Mass ]:
298.154205

[ PSA ]:
87.89000

[ LogP ]:
-0.08

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.691

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

N-Benzyl-2-chloro-9-methyl-9H-purin-6-amin
2-Aminoethanol
methyl iodide
2-amino-1,9-dihydro-9-methyl-6H-purin-6-one
Benzylamine
N-BENZYL-2-CHLORO-9H-PURIN-6-AMINE
2,6-Dichloropurine
Methanol
6-Chloro-2-fluoropurine

DownStream

Articles

Inhibition of cyclin-dependent kinases by purine analogues.

Eur. J. Biochem. 224 , 771, (1994)

While testing purines related to the non-specific protein kinase inhibitors N6-dimethylaminopurine and N6-(delta 2-isopentenyl)adenine as potential inhibitors of the p34cdc2/cyclin B kinase, we discov...

Steering neuronal growth cones by shifting the imbalance between exocytosis and endocytosis.

J. Neurosci. 34(21) , 7165-78, (2014)

Extracellular molecular cues guide migrating growth cones along specific routes during development of axon tracts. Such processes rely on asymmetric elevation of cytosolic Ca(2+) concentrations across...

Cellular effects of olomoucine, an inhibitor of cyclin-dependent kinases.

Biol. Cell 83 , 105-120, (1995)

Olomoucine (2-(2-hydroxyethylamino)-6-benzylamino-9-methylpurine) has been recently described as a competitive inhibitor (ATP-binding site) of the cell cycle regulating p34cdc2/cyclin B, p33cdk2/cycli...

Olomoucine II
Iso-Olomoucine
N9-Isopropylolomoucine
(1R,5S)-1,2,3,4,5,6-Hexahydro-3-(2-propen-1-yl)-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one
1-(beta-Hydroxyethyl)-6,7-dimethoxy-3,4-dihydroisoquinoline
5-Chloromethyl-2,3-dimethoxy-6-me-thyl-1,4-benzoquinone
N-[3-(1H-benzimidazol-2-yl)propyl]-N-methylacetamide
Methyl[(2,4,6-trimethylphenyl)methyl]amine
2-(3,4-Dimethoxyphenyl)cyclohexan-1-one
L-allopyranose
(2S)-I+/-,I+/--Diphenyl-2-azetidinemethanol
Moxonidine metabolite M1
[2-(Aminomethyl)-1-(4-methylphenyl)cyclopropyl]methanol

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