Calyculin A

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Names

[ CAS No. ]:
101932-71-2

[ Name ]:
Calyculin A

[Synonym ]:
Calyculin A,N-[(3S)-[4-(1E)-3-[(2R,3R,4R,7S,8S,9R)-2-[(1S,3S,4S,5R,7E,9E,11E,13Z)-14-Cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentamethyl-7,9,11,13-tetradecatetraenyl]-9-hydroxy-4,4,8-trimethyl-3-(phosphonooxy)-1,6-dioxaspiro[4.5]dec-7-yl]-1-propenyl]-2-o
MFCD00133156
Calyculin A

Chemical & Physical Properties

[ Density]:
1.25g/cm3

[ Molecular Formula ]:
C50H81N4O15P

[ Molecular Weight ]:
1009.17000

[ Exact Mass ]:
1008.54000

[ PSA ]:
296.80000

[ LogP ]:
5.07988

[ Index of Refraction ]:
1.57

[ Storage condition ]:
2-8℃

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301 + H311 + H331-H315

[ Precautionary Statements ]:
P261-P280-P301 + P310-P311

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T: Toxic;

[ Risk Phrases ]:
23/24/25-38

[ Safety Phrases ]:
36/37/39-45

[ RIDADR ]:
UN 3462 6.1/PG 3

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1(a)

Articles

A novel receptor cross-talk between the ATP receptor P2Y2 and formyl peptide receptors reactivates desensitized neutrophils to produce superoxide

Exp. Cell Res. 323(1) , 209-17, (2014)

Neutrophils express several G-protein coupled receptors (GPCRs) and they cross regulate each other. We described a novel cross-talk mechanism in neutrophils, by which signals generated by the receptor...

Detachment-induced autophagy in three-dimensional epithelial cell cultures.

Meth. Enzymol. 452 , 423-39, (2009)

Integrin-mediated cell adhesion to extracellular matrix (ECM) is critical for normal epithelial cell survival; cells deprived of ECM contact rapidly undergo apoptotic cell death, termed anoikis. Recen...

Unique features of the okadaic acid activity class of tumor promoters.

J. Cancer Res. Clin. Oncol. 125 , 150-155, (1999)

Following the first report of tumor promotion by okadaic acid in 1988, we further identified additional tumor promoters of the okadaic acid activity class, such as calyculin A and microcystin-LR. Howe...


More Articles

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