Zardaverine

Suppliers

Names

[ CAS No. ]:
101975-10-4

[ Name ]:
Zardaverine

[Synonym ]:
3-[4-(difluoromethoxy)-3-methoxyphenyl]-1H-pyridazin-6-one
3-pyridazinol, 6-[4-(difluoromethoxy)-3-methoxyphenyl]-
Zardaverine
3(2H)-Pyridazinone, 6-[4-(difluoromethoxy)-3-methoxyphenyl]-
6-[4-(Difluoromethoxy)-3-methoxyphenyl]-3(2H)-pyridazinone
zardaverinum
zardaverina
6-[4-(Difluoromethoxy)-3-methoxyphenyl]pyridazin-3(2H)-one

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C₁₂H₁₀F₂N₂O₃

[ Molecular Weight ]:
268.216

[ Exact Mass ]:
268.065948

[ PSA ]:
64.21000

[ LogP ]:
0.90

[ Index of Refraction ]:
1.555

[ Storage condition ]:
2-8℃

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Uncovering caffeine's adenosine A2A receptor inverse agonism in experimental parkinsonism.

ACS Chem. Biol. 9(11) , 2496-501, (2014)

Caffeine, the most consumed psychoactive substance worldwide, may have beneficial effects on Parkinson's disease (PD) therapy. The mechanism by which caffeine contributes to its antiparkinsonian effec...

Dopamine receptors D3 and D5 regulate CD4(+)T-cell activation and differentiation by modulating ERK activation and cAMP production.

J. Neuroimmunol. 284 , 18-29, (2015)

Dopamine receptors have been described in T-cells, however their signalling pathways coupled remain unknown. Since cAMP and ERKs play key roles regulating T-cell physiology, we aim to determine whethe...

Phenotype-based screening of mechanistically annotated compounds in combination with gene expression and pathway analysis identifies candidate drug targets in a human squamous carcinoma cell model.

J. Biomol. Screen. 11(5) , 457-68, (2006)

The squamous cell carcinoma HeLa cell line and an epithelial cell line hTERT-RPE with a nonmalignant phenotype were interrogated for HeLa cell selectivity in response to 1267 annotated compounds repre...