4-Chloro-3-nitroanisole

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Names

[ CAS No. ]:
10298-80-3

[ Name ]:
4-Chloro-3-nitroanisole

[Synonym ]:
4-chloro-3-nitrophenyl methyl ether
2-Chloro-5-Methoxynitrobenzene
1-Chloro-2-nitro-4-methoxybenzene
4-Chloro-3-nitroanisole
dioxoaMine
1-Chloro-4-methoxy-2-nitrobenzene
EINECS 233-674-1
4-methoxy-2-nitrochlorobenzene
2-fluoronitrobenzene
4-Chlor-3-nitro-anisol
MFCD00007077
3-NITRO-4-CHLOROANISOLE
4-chloro-3-nitro-anisol
2-Nitro-4-methoxychlorobenzene
Benzene, 1-chloro-4-methoxy-2-nitro-
4-chloro-3-nitro-anisole

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
293.3±20.0 °C at 760 mmHg

[ Melting Point ]:
41-43 °C(lit.)

[ Molecular Formula ]:
C7H6ClNO3

[ Molecular Weight ]:
187.580

[ Flash Point ]:
131.2±21.8 °C

[ Exact Mass ]:
187.003616

[ PSA ]:
55.05000

[ LogP ]:
2.65

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.560

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
BZ8580000
CHEMICAL NAME :
Anisole, 4-chloro-3-nitro-
CAS REGISTRY NUMBER :
10298-80-3
BEILSTEIN REFERENCE NO. :
0640872
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C7-H6-Cl-N-O3
MOLECULAR WEIGHT :
187.59
WISWESSER LINE NOTATION :
WNR BG EO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#04759

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
BZ8580000

[ HS Code ]:
29093090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-Methoxy-2-nitroaniline
  • m-nitroanisole
  • Potassium Methyl Sulfate
  • Sodium Methylate

DownStream

  • diethyl 2-(4-methoxy-2-nitrophenyl)propanedioate
  • 5-METHOXYBENZO[D]THIAZOLE-2-THIOL
  • 6-Methoxyindole
  • 5-HYDROXYOXINDOLE
  • N-[2-[2-hydroxy-4-(methanesulfonamido)-5-phenoxyphenyl]-2-oxoethyl]formamide
  • 4-methoxy-1-[(4-methoxy-2-nitrophenyl)disulfanyl]-2-nitrobenzene
  • 3-nitro-4-mercapto-toluene
  • 4-methoxy-2-nitrobenzenethiol
  • formamidomethyl-2-methoxy-4-methanesulfonylamino- 5-Phenoxy phenylethanone
  • 2-amino-4-methoxybenzenethiol

Customs

[ HS Code ]: 2909309090

[ Summary ]:
2909309090 other aromatic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Articles

Synthesis and antiinflammatory activity of 7-methanesulfonylamino-6-phenoxychromones. Antiarthritic effect of the 3-formylamino compound (T-614) in chronic inflammatory disease models.

Chem. Pharm. Bull. 48(1) , 131-9, (2000)

A group of derivatives of 7-methanesulfonylamino-6-phenoxychromone (1) at the pyrone and phenoxy rings was synthesized starting with 4-chloro-3-nitroanisole and evaluated against acute and chronic inf...


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Related Compounds

  • 4-CHLORO-3-NITROANISOLE
  • 4-chloro-3-(2-phenylnaphthalen-1-yl)pyridine
  • 4-Chloro-3-ethylphenol
  • [4-chloro-3-(methylcarbamoyloxy)phenyl]-dimethylazanium,chloride
  • 4-chloro-3-[2-(4-chlorophenyl)indolizine-3-carbonyl]-N-methyl-N-phenylbenzenesulfonamide
  • 4-Chloro-3-methoxyphenol