3,5-Diiodo-L-thyronine

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Names

[ CAS No. ]:
1041-01-6

[ Name ]:
3,5-Diiodo-L-thyronine

[Synonym ]:
O-(4-Hydroxyphenyl)-3,5-diiodotyrosine
3,5-Diiodo-L-thyronine
Tyrosine, O-(4-hydroxyphenyl)-3,5-diiodo-
L-O-(4-hydroxyphenyl)-3,5-diiodo-Tyrosine
L-tyrosine, O-(4-hydroxyphenyl)-3,5-diiodo-
3,5-Diiodo-4-(4-hydroxyphenoxy)-L-phenylalanine
EINECS 213-867-7
L-(+)-3,5-Diiodothyronine
(2S)-2-amino-3-[4-(4-hydroxyphenoxy)-3,5-diiodophenyl]propanoic acid
O-(4-Hydroxyphenyl)-3,5-diiodo-L-tyrosine
3,5-T2 O-(4-Hydroxyphenyl)-3,5-diiodo-L-tyrosine
3,5-di-iodo-L-thyronine
L-Tyrosine, O- (4-hydroxyphenyl)-3,5-diiodo-
Alanine, 3-[4- (p-hydroxyphenoxy)-3,5-diiodophenyl]-, L-
MFCD00064987

Chemical & Physical Properties

[ Density]:
2.1±0.1 g/cm3

[ Boiling Point ]:
559.4±50.0 °C at 760 mmHg

[ Melting Point ]:
255-260 °C (dec.)

[ Molecular Formula ]:
C15H13I2NO4

[ Molecular Weight ]:
525.077

[ Flash Point ]:
292.1±30.1 °C

[ Exact Mass ]:
524.893372

[ PSA ]:
92.78000

[ LogP ]:
3.78

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.726

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2922509090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • (2S)-3-[4-(4-hydroxyphenoxy)-3,5-diiodophenyl]-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid
  • 1-oxaspiro[2.5]octa-4,7-dien-6-one
  • 3,5-Diiodo-L-tyrosine dihydrate
  • 4-Hydroxybenzyl alcohol
  • L-Tyrosine
  • H-Tyr-OMe
  • Boc-L-Tyrosine methyl ester
  • BOC-3,5-DIIODO-TYR-OME

DownStream

  • L-thyroxine
  • l-tyrosine, o-(4-hydroxyphenyl)-3,5-diiodo-, methyl ester
  • thyronine
  • liothyronine

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Administration of 3,5-diiodothyronine (3,5-T2) causes central hypothyroidism and stimulates thyroid-sensitive tissues.

J. Endocrinol. 221(3) , 415-27, (2014)

In general, 3,5-diiodothyronine (3,5-T2) increases the resting metabolic rate and oxygen consumption, exerting short-term beneficial metabolic effects on rats subjected to a high-fat diet. Our aim was...

In Vitro, Ex Vivo, and In Vivo Determination of Thyroid Hormone Modulating Activity of Benzothiazoles.

Toxicol. Sci. 146 , 254-64, (2015)

As in vitro assays are increasingly used to screen chemicals for their potential to produce endocrine disrupting adverse effects, it is important to understand their predictive capacity. The potential...

Ion pair hollow fiber liquid-liquid-liquid microextraction combined with capillary electrophoresis-ultraviolet detection for the determination of thyroid hormones in human serum.

J. Chromatogr. A. 1356 , 23-31, (2014)

In this study, a novel, inexpensive, sensitive and selective analytical method that combines ion pair hollow fiber liquid-liquid-liquid microextraction (IP-HF-LLLME) with capillary electrophoresis-ult...


More Articles

Related Compounds

  • BOC-3,5-DIIODO-L-THYRONINE
  • N-formyl-3,5-diiodo-L-thyronine
  • 3'-Acetyl-3,5-diiodo-L-thyronine
  • 3,5-diiodo-L-thyronine methyl ester
  • 3,5-diiodo-L-thyronine methyl ester
  • 3,5-diiodo-O'-methyl-L-thyronine