4-Hydroxy-3-nitrophenylacetic acid

Names

[ CAS No. ]:
10463-20-4

[ Name ]:
4-Hydroxy-3-nitrophenylacetic acid

[Synonym ]:
EINECS 233-948-0
4-Hydroxy-3-nitrophenylacetic Acid
2-(4-Hydroxy-3-nitrophenyl)acetic acid
MFCD00007122

Chemical & Physical Properties

[ Density]:
1.435 g/cm3

[ Boiling Point ]:
302.9ºC at 760 mmHg

[ Melting Point ]:
146-148 °C(lit.)

[ Molecular Formula ]:
C₈H₇NO₅

[ Molecular Weight ]:
197.14500

[ Flash Point ]:
137ºC

[ Exact Mass ]:
197.03200

[ PSA ]:
103.35000

[ LogP ]:
1.45070

[ Vapour Pressure ]:
5.38E-07mmHg at 25°C

[ Storage condition ]:
−20°C

MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2918290000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

(3ALPHAR,6ALPHAS)-TETRAHYDRO-1H-CYCLOPENTA[C]FURAN-1,3(3AH)-DIONE(3)
4-METHOXY-3-NITRO-BENZENEACETIC ACID METHYL ESTER
Methyl 2-(3-amino-4-hydroxyphenyl)acetate
Methyl 2-(4-hydroxy-3-nitrophenyl)acetate
2-(3-OXO-3,4-DIHYDRO-2H-1,4-BENZOXAZIN-6-YL)ACETIC ACID
2,2,2-trifluoro-N-[2-(4-methoxy-3-nitrophenyl)ethyl]acetamide
Methyl 2-(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)acetate
N-[2-hydroxy-5-(2-methylaminoethyl)phenyl]methanesulfonamide
2-(4-Chlorophenyl)-5-benzoxazoleacetic Acid
(4-METHOXY-3-NITROPHENYL)ACETIC ACID

Customs

[ HS Code ]: 2918290000

[ Summary ]:
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

Articles

B cells in T follicular helper cell development and function: separable roles in delivery of ICOS ligand and antigen.

J. Immunol. 192(7) , 3166-79, (2014)

B cells are required for follicular Th (Tfh) cell development, as is the ICOS ligand (ICOS-L); however, the separable contributions of Ag and ICOS-L delivery by cognate B cells to Tfh cell development...

A role for lysosomal-associated protein transmembrane 5 in the negative regulation of surface B cell receptor levels and B cell activation.

J. Immunol. 185(1) , 294-301, (2010)

Mechanisms by which cell surface levels of the BCR are regulated remain largely unknown. We found that B cells lacking the lysosomal-associated protein transmembrane 5 (LAPTM5) expressed higher levels...

The pericyte and stromal cell marker CD248 (endosialin) is required for efficient lymph node expansion.

Eur. J. Immunol. 40(7) , 1884-9, (2010)

CD248 is a cell surface receptor that specifically identifies fibroblasts and pericytes during development and in association with cancer and inflammation. However, its function is poorly defined and ...