4-nitro-1H-indole-3-carbaldehyde

Names

[ CAS No. ]:
10553-11-4

[ Name ]:
4-nitro-1H-indole-3-carbaldehyde

[Synonym ]:
4-Nitro-3-formylindol
3-Formyl-4-nitroindole
1H-Indole-3-carboxaldehyde,4-nitro
4-Nitroindol-3-carbaldehyd
4-Nitroindole-3-carboxaldehyde
4-nitro-3-indolecarbaldehyde
4-nitro-indole-3-carbaldehyde

Chemical & Physical Properties

[ Density]:
1.517g/cm3

[ Boiling Point ]:
441.47ºC at 760 mmHg

[ Melting Point ]:
189-193ºC

[ Molecular Formula ]:
C9H6N2O3

[ Molecular Weight ]:
190.15600

[ Flash Point ]:
220.794ºC

[ Exact Mass ]:
190.03800

[ PSA ]:
78.68000

[ LogP ]:
2.41180

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.765

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
26-36/37

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-Nitroindole
  • N,N-Dimethylformamide
  • 1,3-bis(trifluoroacetyl)-2-(4-nitro-3-indolyl)-4-imidazoline
  • 2-Methyl-3-nitroaniline
  • Indole-3-carboxaldehyde
  • ETHYL-N-(2-METHYL-3-NITROPHENYL)FORMIMIDATE
  • N'-(2-methyl-3-nitrophenyl)-N,N-dimethylformamidine

DownStream

  • 4-Nitroindole
  • 1H-Indole-3-methanamine,N,N-dimethyl-4-nitro-
  • 3-HydroxyMethyl-4-nitroindole
  • tert-butyl 3-formyl-4-nitroindole-1-carboxylate

Articles

Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators.

J. Med. Chem. 54 , 5320, (2011)

Tryptophan catabolism mediated by indoleamine 2,3-dioxygenase (IDO) is an important mechanism of peripheral immune tolerance contributing to tumoral immune resistance. IDO inhibition is thus an active...

Tetrahedron 46 , 6085, (1990)

Molesworth, P., P.; et al.

Aust. J. Chem. 63 , 813, (2010)


More Articles

Related Compounds

  • 2-chloro-5-methoxy-6-methyl-4-nitro-1H-indole-3-carbaldehyde
  • 4-nitro-1H-indole-3-carbonitrile
  • 4-methyl-7-nitro-1H-indole-3-carbaldehyde
  • 6-Nitro-1H-indole-3-carbaldehyde
  • 5-Nitro-1H-indole-3-carbaldehyde
  • 2-Nitro-1H-indole-3-carbaldehyde