4-nitro-1H-indole-3-carbaldehyde

4-nitro-1H-indole-3-carbaldehyde Structure
4-nitro-1H-indole-3-carbaldehyde structure
Common Name 4-nitro-1H-indole-3-carbaldehyde
CAS Number 10553-11-4 Molecular Weight 190.15600
Density 1.517g/cm3 Boiling Point 441.47ºC at 760 mmHg
Molecular Formula C9H6N2O3 Melting Point 189-193ºC
MSDS USA Flash Point 220.794ºC
Symbol GHS07
GHS07
Signal Word Warning

Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators.

J. Med. Chem. 54 , 5320, (2011)

Tryptophan catabolism mediated by indoleamine 2,3-dioxygenase (IDO) is an important mechanism of peripheral immune tolerance contributing to tumoral immune resistance. IDO inhibition is thus an active area of research in drug development. Recently, our group ...

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