Clinafloxacin

Suppliers

Names

[ Name ]:
Clinafloxacin

[Synonym ]:
MFCD00865120
Clinafloxacin
7-(3-aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylic acid

Chemical & Physical Properties

[ Density]:
1.573 g/cm3

[ Boiling Point ]:
592.3ºC at 760 mmHg

[ Melting Point ]:
253-258ºC

[ Molecular Formula ]:
C₁₇H₁₇ClFN₃O₃

[ Molecular Weight ]:
365.78700

[ Flash Point ]:
312ºC

[ Exact Mass ]:
365.09400

[ PSA ]:
88.56000

[ LogP ]:
3.12980

[ Vapour Pressure ]:
7.14E-15mmHg at 25°C

[ Index of Refraction ]:
1.684

[ Storage condition ]:
2-8°C

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H361d

[ Precautionary Statements ]:
P281

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
VB1800600

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Pharmacokinetics of danofloxacin and N-desmethyldanofloxacin in adult horses and their concentration in synovial fluid.

J. Vet. Pharmacol. Ther. 38(2) , 123-9, (2015)

The objectives of this study were to investigate the pharmacokinetics of danofloxacin and its metabolite N-desmethyldanofloxacin and to determine their concentrations in synovial fluid after administr...

Accumulation of garenoxacin by Bacteroides fragilis compared with that of five fluoroquinolones.

J. Antimicrob. Chemother. 52(4) , 605-9, (2003)

Garenoxacin is a novel des-F(6)-quinolone with good anti-anaerobe activity. The accumulation of garenoxacin and five other quinolones in the presence and absence of a variety of efflux pump inhibitors...

Synthesis and antibacterial activity of novel pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid derivatives carrying the 3-cyclopropylaminomethyl-4-substituted-1-pyrrolidinyl group as a C-10 substituent.

J. Med. Chem. 51 , 3238-49, (2008)

Novel pyrido[1,2,3- de][1,4]benzoxazine-6-carboxylic acid derivatives 5- 9 carrying a 3-cyclopropylaminomethyl-4-substituted-1-pyrrolidinyl moiety at the C-10 position were synthesized and their in vi...