Glycidyl methacrylate

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Names

[ CAS No. ]:
106-91-2

[ Name ]:
Glycidyl methacrylate

[Synonym ]:
Glycidyl Methacrylate
Methacrylic Acid Glycidyl Ester
2-((Methacryloxy)methyl)oxirane
oxiran-2-ylmethyl methacrylate
EINECS 203-441-9
Glycidyl methacrylate(GMA)
MFCD00005137
2,3-epoxypropyl methacrylate

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
189.0 at 760 mmHg

[ Melting Point ]:
-52°C

[ Molecular Formula ]:
C₇H₁₀O₃

[ Molecular Weight ]:
142.152

[ Flash Point ]:
76.1

[ Exact Mass ]:
142.062988

[ PSA ]:
38.83000

[ LogP ]:
1.39

[ Vapour Pressure ]:
0.6±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.458

[ Storage condition ]:
Refrigerator

[ Stability ]:
Unstable. Light sensitive. May be stabilized with around 100ppm MEHQ. Refrigerate.

[ Water Solubility ]:
0.5-1.0 g/100 mL at 20 ºC

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OZ4375000

CHEMICAL NAME :: Methacrylic acid, 2,3-epoxypropyl ester

CAS REGISTRY NUMBER :: 106-91-2

BEILSTEIN REFERENCE NO. :: 0002506

LAST UPDATED :: 199806

DATA ITEMS CITED :: 26

MOLECULAR FORMULA :: C7-H10-O3

MOLECULAR WEIGHT :: 142.17

WISWESSER LINE NOTATION :: T3OTJ B1OVY1&U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 597 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1400 mg/m3/6H

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 390 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 1400 mg/m3/6H

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1400 mg/m3/6H

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 450 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 697 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1400 mg/m3/6H

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2100 mg/kg/30D-I

TOXIC EFFECTS :: Behavioral - food intake (animal) Gastrointestinal - ulceration or bleeding from stomach Kidney, Ureter, Bladder - changes primarily in glomeruli

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 206 mg/m3/6H/26W-I

TOXIC EFFECTS :: Liver - changes in liver weight Endocrine - changes in spleen weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 40 ppm/6H/9D-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - deviated nasal septum Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 206 mg/m3/6H/26W-I

TOXIC EFFECTS :: Brain and Coverings - other degenerative changes Cardiac - EKG changes not diagnostic of specified effects Blood - changes in erythrocyte (RBC) count

TYPE OF TEST :: Cytogenetic analysis

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 78 umol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 249,55,1991 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-THE NETHERLANDS:TWA 0.04 ppm (0.24 mg/m3) JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1341 No. of Facilities: 95 (estimated) No. of Industries: 2 No. of Occupations: 7 No. of Employees: 4002 (estimated)

Safety Information

[ Symbol ]:

GHS05, GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302 + H332-H311-H314-H317-H341-H350-H360F-H370

[ Precautionary Statements ]:
P201-P260-P280-P305 + P351 + P338-P310

[ Target Organs ]:
Respiratory Tract

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R20/21/22;R36/38;R43

[ Safety Phrases ]:
S26-S28-S28A-S45-S36/37-S53

[ RIDADR ]:
UN 2810 6.1/PG 3

[ WGK Germany ]:
2

[ RTECS ]:
OZ4375000

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
2916140000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Allyl methacrylate
Glycidol
Epichlorohydrin
Methylpropenal
Potassium methacrylate
Methacrylic acid
Sodium tert-butoxide
Methacryloyl chloride
2-Propenoic acid, 2-methyl-, (2-oxo-1,3-dioxolan-4-yl)methyl ester

DownStream

Methacrylic acid
(±)-Glycidol
(S)-glycidyl methacrylate
UNII:OL56191M6N
Glycidol
Glyceryl monomethacrylate
[3-(4-formylphenoxy)-2-hydroxypropyl] 2-methylprop-2-enoate
Allyl methacrylate
Thiiran-2-ylmethyl methacrylate

Customs

[ HS Code ]: 2916140000

[ Summary ]:
2916140000. other esters of methacrylic acid. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:80.0%

Articles

Organic monolith frits encased in polyether ether ketone tubing with improved durability for liquid chromatography.

J. Sep. Sci. 38 , 2938-44, (2015)

This study introduces a preparation method for polymer-encased monolith frits with improved durability for liquid chromatography columns. The inner surface of the polyether ether ketone tubing is pret...

Encapsulation of porcine pancreatic islets within an immunoprotective capsule comprising methacrylated glycol chitosan and alginate.

J. Biomed. Mater. Res. B. Appl. Biomater. 103(3) , 503-18, (2015)

Encapsulation of cells in biocompatible polymer matrices represents a powerful tool for cell-based therapies and therapeutic delivery systems. This technology has successfully been used to deliver pan...

Fast determination of 22 sulfonamides from chicken breast muscle using core-shell nanoring amino-functionalized superparamagnetic molecularly imprinted polymer followed by liquid chromatography-tandem mass spectrometry.

J. Chromatogr. A. 1345 , 17-28, (2014)

A novel, simple and sensitive method was developed for the simultaneous determination of 22 sulfonamides (SAs) in chicken breast muscle by using the dispersive micro-solid-phase extraction (d-μ-SPE) p...

(R)-glycidyl methacrylate
(S)-glycidyl methacrylate
Poly(ethylene-co-glycidyl methacrylate)
poly(glycidyl methacrylate) macromolecule
Poly(pentafluorostyrene-co-glycidyl methacrylate)
Poly(glycidyl methacrylate-co-ethylene dimethacrylate)
2-amino-3-(4-ethyl-3,5-dimethyl-1H-pyrazol-1-yl)-2-methylpropanamide
Methyl 5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridine-8-carboxylate
1-(2-Methoxy-4-nitrophenyl)-5-methyl-1h-1,2,4-triazole
6,7,8,9-Tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-9-ol
3-(dimethyl-1H-1,2,4-triazol-1-yl)-2-(propylamino)propanoic acid
(6,7,8,9-Tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-9-yl)methanamine
methyl 2-amino-4-(dimethyl-1H-1,2,4-triazol-1-yl)-2-methylbutanoate
3-(Trifluoromethyl)-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-9-amine
2-Amino-4-(3,5-dimethyl-1h-1,2,4-triazol-1-yl)-2-methylbutanamide
4-[(E)-3-hydroxybut-1-enyl]-2-methoxyphenol

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