Ethambutol dihydrochloride
Suppliers
Names
[ CAS No. ]:
1070-11-7
[ Name ]:
Ethambutol dihydrochloride
[Synonym ]:
2,2'-(Ethane-1,2-diylbis(azanediyl))bis(butan-1-ol) dihydrochloride
(S,S)-N,N'-Bis(1-hydroxy-2-butyl)ethylenediamine Dihydrochloride
(2S,2'S)-2,2'-(Ethane-1,2-diylbis(azanediyl))bis(butan-1-ol) dihydrochloride
(S,S)-2,2'-(1,2-Ethanediyldiimino)bis-1-butanol Dihydrochloride
(2S,2'S)-2,2'-(Ethane-1,2-diyldiimino)dibutan-1-ol dihydrochloride
Ethambutol hydrochloride
Ethambutol dihydrochloride
(2S,2'S)-2,2'-(1,2-Ethanediyldiimino)di(1-butanol) dihydrochloride
1-Butanol, 2,2'-(1,2-ethanediyldiimino)bis-, (2S,2'S)-, hydrochloride (1:2)
MFCD00216025
EINECS 213-970-7
2,2'-[1,2-Ethanediyldi(imino)]di(1-butanol) dihydrochloride
Chemical & Physical Properties
[ Boiling Point ]:
345.3ºC at 760 mmHg
[ Melting Point ]:
198-200°C
[ Molecular Formula ]:
C10H26Cl2N2O2
[ Molecular Weight ]:
277.232
[ Flash Point ]:
113.7ºC
[ Exact Mass ]:
276.137146
[ PSA ]:
64.52000
[ LogP ]:
2.09320
[ Vapour Pressure ]:
3.35E-07mmHg at 25°C
[ Storage condition ]:
Refrigerator
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- EL3854000
- CHEMICAL NAME :
- 1-Butanol, 2,2'-(ethylenediimino)di-, dihydrochloride, (+)-
- CAS REGISTRY NUMBER :
- 1070-11-7
- LAST UPDATED :
- 199706
- DATA ITEMS CITED :
- 14
- MOLECULAR FORMULA :
- C10-H24-N2-O2.2Cl-H
- MOLECULAR WEIGHT :
- 277.28
- WISWESSER LINE NOTATION :
- Q1Y2&M2MY2&1Q &GH 2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 45 mg/kg/3D-I
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - visual field changes Sense Organs and Special Senses (Eye) - effect, not otherwise specified
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 46 mg/kg/3D-I
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - visual field changes
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 720 mg/kg/48D
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - visual field changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 6800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 8900 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 230 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 31200 mg/kg/22W-C
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - chronic pulmonary edema Cardiac - other changes Liver - other changes
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
- TYPE OF TEST :
- Micronucleus test
MUTATION DATA
- TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 12500 ug/kg
- REFERENCE :
- IRLCDZ IRCS Medical Science: Library Compendium. (Lancaster, UK) V.3-11, 1975-83. For publisher information, see IMSCE2. Volume(issue)/page/year: 10,135,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5347 No. of Facilities: 93 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 590 (estimated) No. of Female Employees: 430 (estimated)
Safety Information
[ Symbol ]:
GHS08
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H360
[ Precautionary Statements ]:
P201-P308 + P313
[ Personal Protective Equipment ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
[ Hazard Codes ]:
T: Toxic;
[ Risk Phrases ]:
R61
[ Safety Phrases ]:
S53-S22-S36/37/39-S45
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
EL3854000
[ HS Code ]:
2922191000
Customs
[ HS Code ]: 2922191000
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