Perindopril erbumine

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Names

[ CAS No. ]:
107133-36-8

[ Name ]:
Perindopril erbumine

[Synonym ]:
Aceon
S 9490-3
PrestariuM
(2S,3aS,7aS)-1-[(2S)-2-{[(1S)-1-(ethoxycarbonyl)butyl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid - 2-methylpropan-2-amine (1:1) (non-preferred name)
(2S,3aS,7aS)-1-[(2S)-2-{[(2S)-1-Ethoxy-1-oxopentan-2-yl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid - 2-methylpropan-2-amine (1:1) (non-preferred name)
acide (2S,3aS,7aS)-1-[(2S)-2-{[(1S)-1-(éthoxycarbonyl)butyl]amino}propanoyl]octahydro-1H-indole-2-carboxylique - 2-méthylpropan-2-amine (1:1)
McN-A 2833-109
McN-A-2833-109
Perinodpril ErbiMune
ButylaMiniperindopril
Perindoril
Perindopril erbumine
MFCD02313824
Perindopril tert-butylamine
(2S,3aS,7aS)-1-[(2S)-2-{[(2S)-1-Ethoxy-1-oxo-2-pentanyl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid - 2-methyl-2-propanamine (1:1)
S-9490-3
Perindopril t-Butylamine Salt
(2S,3aS,7aS)-1-((S)-N-((S)-1-Carboxybutyl)alanyl)hexahydro-2-indolinecarboxylic Acid 1-Ethyl Ester compound with tert-Butylamine (1:1)
Procaptan
Unii-1964X464oj
Coversyl
(2S,3aS,7aS)-1-[(2S)-2-{[(1S)-1-(Ethoxycarbonyl)butyl]amino}propanoyl]octahydro-1H-indol-2-carbonsäure--2-methylpropan-2-amin(1:1)
(2S-(1(R*(R*)),2a,3ab,7ab))-1-(2-((1-(Ethoxycarbonyl)butyl)amino)-1-oxopropyl)octahydro-1H-indole-2-carboxylic Acid compd. with 2-Methyl-2-propanamine (1:1)
Perinodopril
Coversum
(2S,3aS,7aS)-1-[(2S)-2-{[(1S)-1-(ethoxycarbonyl)butyl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid - 2-methylpropan-2-amine (1:1)
Perindopril t-Butylamine

Chemical & Physical Properties

[ Density]:
1.15 g/cm3

[ Boiling Point ]:
537.4ºC at 760mmHg

[ Melting Point ]:
126-128ºC

[ Molecular Formula ]:
C23H43N3O5

[ Molecular Weight ]:
441.605

[ Flash Point ]:
278.8ºC

[ Exact Mass ]:
441.320282

[ PSA ]:
121.96000

[ LogP ]:
3.71330

[ Storage condition ]:
-20°C Freezer

[ Water Solubility ]:
H2O: soluble10mg/mL, clear

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
NL5999600

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Perindopril
  • N-[(2S)-1-Ethoxy-1-oxo-2-pentanyl]-L-alanine
  • tert-Butylamine
  • (2S,3aS,7aS)-phenylmethyl octahydroindole-2-carboxylate hydrochloride
  • N-[1(S)-ethoxycarbonyl-1-butyl]-(S)-alanyl chloride hydrochloride
  • L-Octahydroindole-2-carboxylic acid

DownStream

  • Perindoprilat
  • Perindopril Diketopiperazine
  • Perindopril

Articles

Clopidogrel bioactivation and risk of bleeding in patients cotreated with angiotensin-converting enzyme inhibitors after myocardial infarction: a proof-of-concept study.

Clin. Pharmacol. Ther. 96(6) , 713-22, (2014)

Clopidogrel is an oral antiplatelet prodrug, the majority of which is hydrolyzed to an inactive metabolite by hepatic carboxylesterase 1 (CES1). Most angiotensin-converting enzyme inhibitors (ACEIs) a...

Precision-cut liver slices as a model for the early onset of liver fibrosis to test antifibrotic drugs.

Toxicol. Appl. Pharmacol. 274(2) , 328-38, (2014)

Induction of fibrosis during prolonged culture of precision-cut liver slices (PCLS) was reported. In this study, the use of rat PCLS was investigated to further characterize the mechanism of early ons...

Hepatic, intestinal, renal, and plasma hydrolysis of prodrugs in human, cynomolgus monkey, dog, and rat: implications for in vitro-in vivo extrapolation of clearance of prodrugs.

Drug Metab. Dispos. 42(9) , 1522-31, (2014)

Hydrolysis plays an important role in metabolic activation of prodrugs. In the current study, species and in vitro system differences in hepatic and extrahepatic hydrolysis were investigated for 11 pr...


More Articles

Related Compounds

  • Perindopril erbumine monohydrate
  • Perindopril-d4 erbumine
  • Perindopril acyl-β-D-glucuronide
  • Perindopril Diketopiperazine
  • Perindopril Impurity 27
  • Perindopril Impurity 16
  • 2-(1-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroquinolin-2-yl)acetic acid
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 3-[N-(2-nitrophenyl)acetamido]propanoic acid
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • 1-Phenylpiperidine-2-carboxamide
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 7-[4-(4-Benzo[b]thien-4-yl-1-piperazinyl)butoxy]-4-hydroxy-2(1h)-quinolinone