Perindopril erbumine

Modify Date: 2024-01-02 07:10:15

Perindopril erbumine Structure
Perindopril erbumine structure
 Common Name Perindopril erbumine
CAS Number 107133-36-8 Molecular Weight 441.605
Density 1.15 g/cm3 Boiling Point 537.4ºC at 760mmHg
Molecular Formula C23H43N3O5 Melting Point 126-128ºC
MSDS Chinese USA Flash Point 278.8ºC

 Use of Perindopril erbumine


Perindopril erbumine is a potent ACE inhibitor of which is used to treat high blood pressure, heart failure or stable coronary artery disease.Target: ACEPerindopril is a long-acting ACE inhibitor. It is used to treat high blood pressure, heart failure or stable coronary artery disease in form of perindopril arginine (trade names include Coversyl, Coversum) or perindopril erbumine (trade name Aceon). According to the Australian government's Pharmaceutical Benefits Scheme website, based on data provided to the Australian Department of Health and Aging by the manufacturer, perindopril arginine and perindopril erbumine are therapeutically equivalent and may be interchanged without differences in clinical effect. However the dose prescribed to achieve the same effect will differ due to different molecular weights for the two forms. Perindopril is one of the most prescribed inhibitors of angiotensin converting enzyme, has a large evidence base, which allows to use it in patients with hypertension, diabetes mellitus type 2, coronary heart disease and chronic heart failure. In this review, the author focused on the evidence of organoprotecting properties of perindopril that lie outside lowering blood pressure.

 Names

Name perindopril erbumine
Synonym More Synonyms

 Perindopril erbumine Biological Activity

Description Perindopril erbumine is a potent ACE inhibitor of which is used to treat high blood pressure, heart failure or stable coronary artery disease.Target: ACEPerindopril is a long-acting ACE inhibitor. It is used to treat high blood pressure, heart failure or stable coronary artery disease in form of perindopril arginine (trade names include Coversyl, Coversum) or perindopril erbumine (trade name Aceon). According to the Australian government's Pharmaceutical Benefits Scheme website, based on data provided to the Australian Department of Health and Aging by the manufacturer, perindopril arginine and perindopril erbumine are therapeutically equivalent and may be interchanged without differences in clinical effect. However the dose prescribed to achieve the same effect will differ due to different molecular weights for the two forms. Perindopril is one of the most prescribed inhibitors of angiotensin converting enzyme, has a large evidence base, which allows to use it in patients with hypertension, diabetes mellitus type 2, coronary heart disease and chronic heart failure. In this review, the author focused on the evidence of organoprotecting properties of perindopril that lie outside lowering blood pressure.
Related Catalog
References

[1]. Vaclavik J, Perindopril in the treatment of hypertension and cardiovascular diseases: evolution continues with the orodispersible dosage form. Vnitr Lek. 2013 Apr;59(4):290-4.

[2]. Napalkov DA. Therapy with perindopril: organoprotection, not just the antihypertensive effect. Kardiologiia. 2012;52(12):80-3.

 Chemical & Physical Properties

Density 1.15 g/cm3
Boiling Point 537.4ºC at 760mmHg
Melting Point 126-128ºC
Molecular Formula C23H43N3O5
Molecular Weight 441.605
Flash Point 278.8ºC
Exact Mass 441.320282
PSA 121.96000
LogP 3.71330
Storage condition -20°C Freezer
Water Solubility H2O: soluble10mg/mL, clear

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases 26-36
RIDADR NONH for all modes of transport
RTECS NL5999600

 Synthetic Route

Perindopril structure

Perindopril

CAS#:82834-16-0

~95%

Perindopril erbumine Structure

Perindopril erbumine

CAS#:107133-36-8

Literature: Dubuffet, Thierry; Lecouve, Jean-Pierre Patent: US2007/43103 A1, 2007 ; Location in patent: Page/Page column 2 ;
N/A structure

N/A

CAS#:1159491-00-5

N-[(2S)-1-Ethoxy-1-oxo-2-pentanyl]-L-alanine structure

N-[(2S)-1-Ethox...

CAS#:82834-12-6

tert-Butylamine structure

tert-Butylamine

CAS#:75-64-9

~62%

Perindopril erbumine Structure

Perindopril erbumine

CAS#:107133-36-8

Literature: KRKA, tovarna zdravil, d.d., Novo mesto Patent: EP1792896 A1, 2007 ; Location in patent: Page/Page column 7-8 ;
tert-Butylamine structure

tert-Butylamine

CAS#:75-64-9

~91%

Perindopril erbumine Structure

Perindopril erbumine

CAS#:107133-36-8

Literature: QUIMICA SINTETICA, S.A. Patent: WO2006/70276 A1, 2006 ; Location in patent: Page/Page column 8 ;
(2S,3aS,7aS)-phenylmethyl octahydroindole-2-carboxylate hydrochloride structure

(2S,3aS,7aS)-ph...

CAS#:86647-57-6

N-[(2S)-1-Ethoxy-1-oxo-2-pentanyl]-L-alanine structure

N-[(2S)-1-Ethox...

CAS#:82834-12-6

tert-Butylamine structure

tert-Butylamine

CAS#:75-64-9

~%

Perindopril erbumine Structure

Perindopril erbumine

CAS#:107133-36-8

Literature: WO2006/137082 A1, ; Page/Page column 11-12 ;
Perindopril structure

Perindopril

CAS#:82834-16-0

tert-Butylamine structure

tert-Butylamine

CAS#:75-64-9

~94%

Perindopril erbumine Structure

Perindopril erbumine

CAS#:107133-36-8

Literature: Dubuffet, Thierry; Lecouve, Jean-Pierre Patent: US2006/178421 A1, 2006 ; Location in patent: Page/Page column 2 ;
(2S,3aS,7aS)-octahydroindole-2-carboxylic acid trimethylsilyl ester structure

(2S,3aS,7aS)-oc...

CAS#:200423-22-9

N-[1(S)-ethoxycarbonyl-1-butyl]-(S)-alanyl chloride hydrochloride structure

N-[1(S)-ethoxyc...

CAS#:869877-95-2

tert-Butylamine structure

tert-Butylamine

CAS#:75-64-9

~%

Perindopril erbumine Structure

Perindopril erbumine

CAS#:107133-36-8

Literature: US2006/211867 A1, ; Page/Page column 4 ;
N-[1(S)-ethoxycarbonyl-1-butyl]-(S)-alanyl chloride hydrochloride structure

N-[1(S)-ethoxyc...

CAS#:869877-95-2

L-Octahydroindole-2-carboxylic acid structure

L-Octahydroindo...

CAS#:80875-98-5

tert-Butylamine structure

tert-Butylamine

CAS#:75-64-9

~%

Perindopril erbumine Structure

Perindopril erbumine

CAS#:107133-36-8

Literature: US2006/211867 A1, ; Page/Page column 3-4 ;

 Articles41

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 Synonyms

Aceon
S 9490-3
PrestariuM
(2S,3aS,7aS)-1-[(2S)-2-{[(1S)-1-(ethoxycarbonyl)butyl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid - 2-methylpropan-2-amine (1:1) (non-preferred name)
(2S,3aS,7aS)-1-[(2S)-2-{[(2S)-1-Ethoxy-1-oxopentan-2-yl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid - 2-methylpropan-2-amine (1:1) (non-preferred name)
acide (2S,3aS,7aS)-1-[(2S)-2-{[(1S)-1-(éthoxycarbonyl)butyl]amino}propanoyl]octahydro-1H-indole-2-carboxylique - 2-méthylpropan-2-amine (1:1)
McN-A 2833-109
McN-A-2833-109
Perinodpril ErbiMune
ButylaMiniperindopril
Perindoril
Perindopril erbumine
MFCD02313824
Perindopril tert-butylamine
(2S,3aS,7aS)-1-[(2S)-2-{[(2S)-1-Ethoxy-1-oxo-2-pentanyl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid - 2-methyl-2-propanamine (1:1)
S-9490-3
Perindopril t-Butylamine Salt
(2S,3aS,7aS)-1-((S)-N-((S)-1-Carboxybutyl)alanyl)hexahydro-2-indolinecarboxylic Acid 1-Ethyl Ester compound with tert-Butylamine (1:1)
Procaptan
Unii-1964X464oj
Coversyl
(2S,3aS,7aS)-1-[(2S)-2-{[(1S)-1-(Ethoxycarbonyl)butyl]amino}propanoyl]octahydro-1H-indol-2-carbonsäure--2-methylpropan-2-amin(1:1)
(2S-(1(R*(R*)),2a,3ab,7ab))-1-(2-((1-(Ethoxycarbonyl)butyl)amino)-1-oxopropyl)octahydro-1H-indole-2-carboxylic Acid compd. with 2-Methyl-2-propanamine (1:1)
Perinodopril
Coversum
(2S,3aS,7aS)-1-[(2S)-2-{[(1S)-1-(ethoxycarbonyl)butyl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid - 2-methylpropan-2-amine (1:1)
Perindopril t-Butylamine
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82834-13-7
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4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
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1375289-11-4
(2R,6R)-2,6-Dibenzyl-2,3,5,6-tetrahydro-1H-imidazo[1,2-a]imidazole
1802738-00-6
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