Eplerenone

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Names

[ Name ]:
Eplerenone

[Synonym ]:
Methyl (4aS,4bR,5aR,6aS,7R,9aS,9bR)-4a,6a-dimethyl-2,5'-dioxo-2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-3H,3'H-spiro[cyclopenta[7,8]phenanthro[4b,5-b]oxirene-7,2'-furan]-10-carboxylate
(4aS,4bR,5aR,6aS,7R,9aS,9bR,10R)-4a,6a-diméthyl-2,5'-dioxo-2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tétradécahydro-3H,3'H-spiro[cyclopenta[7,8]phénanthro[4b,5-b]oxirène-7,2'-furane]-10-carboxylate de méthyle
Methyl-(4aS,4bR,5aR,6aS,7R,9aS,9bR,10R)-4a,6a-dimethyl-2,5'-dioxo-2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-3H,3'H-spiro[cyclopenta[7,8]phenanthro[4b,5-b]oxiren-7,2'-furan]-10-carboxylat
Inspra
EplerenoneC24H3006
9,11a-Epoxy-17-hydroxy-3-oxo-17a-pregn-4-ene-7a,21-dicarboxylic Acid g-Lactone Methyl Ester
Methyl (4aS,4bR,5aR,6aS,7R,9aS,9bR,10R)-4a,6a-dimethyl-2,5'-dioxo-2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-3H,3'H-spiro[cyclopenta[7,8]phenanthro[4b,5-b]oxirene-7,2'-furan]-10-carboxylate
Elperenone
Epleremone
epoxymexrenone
Eplerenone
spiro[cyclopenta[7,8]phenanthro[4b,5-b]oxirene-7(3H),2'(3'H)-furan]-10-carboxylic acid, 2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-4a,6a-dimethyl-2,5'-dioxo-, methyl ester, (4aS,4bR,5aR,6aS,7
Spiro[cyclopenta[7,8]phenanthro[4b,5-b]oxirene-7(3H),2'(3'H)-furan]-10-carboxylic acid, 2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-4a,6a-dimethyl-2,5'-dioxo-, methyl ester, (4aS,4bR,5aR,6aS,7R,9aS,9bR,10R)-
Methyl (4aS,4bR,5aR,7R,9aS,9bR,10R)-4a,6a-dimethyl-2,5'-dioxo-2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-3H,3'H-spiro[cyclopenta[7,8]phenanthro[4b,5-b]oxirene-7,2'-furan]-10-carboxylate
Spiro[cyclopenta[7,8]phenanthro[4b,5-b]oxirene-7(3H),2'(3'H)-furan]-10-carboxylic acid, 2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-4a,6a-dimethyl-2,5'-dioxo-, methyl ester, (4aS,4bR,5aR,6aS,7R,9aS,9bR)-
9,11α-Epoxy-17-hydroxy-3-oxo-17α-pregn-4-ene-7α,21-dicarboxylic Acid γ-Lactone Methyl Ester
EPLERINONE

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
597.9±50.0 °C at 760 mmHg

[ Melting Point ]:
241-243ºC

[ Molecular Formula ]:
C₂₄H₃₀O₆

[ Molecular Weight ]:
414.491

[ Flash Point ]:
259.5±30.2 °C

[ Exact Mass ]:
414.204254

[ PSA ]:
82.20000

[ LogP ]:
1.05

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.587

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
3077

[ HS Code ]:
29322090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

9,11-Eplerenone
Methanol
4'S(4'α),7'α-hexadecahydro-11'α-hydroxy-10'β,13'beta-dimethyl-3',5,20'-trioxospiro[furan-2(3H),17'β-[4,7]metheno(17H)cyclopenta[a]phenanthrene]-5'β(2'H)-carbonitrile
Sodium Methylate
11α-Hydroxy Canrenone
delta-9,11-Canrenone

DownStream

Articles

Lung fibrosis: drug screening and disease biomarker identification with a lung slice culture model and subtracted cDNA Library.

Altern. Lab. Anim. 42(4) , 235-43, (2014)

Pulmonary fibrosis is a progressive and irreversible disorder with no appropriate cure. A practical and effective experimental model that recapitulates the disease will greatly benefit the research co...

Depressor effect of chymase inhibitor in mice with high salt-induced moderate hypertension.

Am. J. Physiol. Heart Circ. Physiol. 309 , H1987-96, (2015)

The aim of the present study was to determine whether long-term high salt intake in the drinking water induces hypertension in wild-type (WT) mice and whether a chymase inhibitor or other antihyperten...

The Other Side of the RAAS: Aldosterone Improves Migration of Cardiac Progenitor Cells.

J. Cell Physiol. 230 , 2829-36, (2015)

Stem cell therapy is a promising new option for patients suffering from heart failure. Though many clinical studies show encouraging results, little is known about the signals which cause stem cells t...

9,11-Eplerenone
21-HYDROXYEPLERENONE
6-Hydroxy Eplerenone
Eplerenone Impurity 9
Eplerenone Impurity 6
Eplerenone Impurity 5
2-Amino-3,3-dimethyl-5-(thiophen-3-yl)pentanoic acid
2-Ethenyl-4,6-difluorophenol
methyl 4-amino-4-(1-methyl-1H-pyrazol-4-yl)butanoate
1-(1-Benzylpiperidin-2-yl)-2-fluoroethan-1-ol
1-(5-chloro-1,3-dimethyl-1H-pyrazol-4-yl)ethane-1,2-diol
(2S)-1-(3-tert-butyl-1-methyl-1H-pyrazol-4-yl)propan-2-ol
2-Bromo-3-[2-(1-hydroxycyclopropyl)ethyl]-6-methoxyphenol
4-Chlorocinnoline-3-sulfonyl chloride
2-Isothiocyanato-2-methyloctanoic acid
3-Methyl-4-[1-(piperidin-4-yl)ethyl]pyridine

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