Eplerenone

Modify Date: 2024-01-02 10:17:37

Eplerenone structure	Common Name	Eplerenone
	CAS Number	107724-20-9	Molecular Weight	414.491
	Density	1.3±0.1 g/cm3	Boiling Point	597.9±50.0 °C at 760 mmHg
	Molecular Formula	C₂₄H₃₀O₆	Melting Point	241-243ºC
	MSDS	USA	Flash Point	259.5±30.2 °C

Use of Eplerenone

Eplerenone is an aldosterone antagonist with an IC50 of 0.36 μM.Target: Mineralocorticoid ReceptorEplerenone is a selective mineralocorticoid receptor antagonist, which has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion. The resulting increased plasma renin activity and aldosterone circulating levels do not overcome the effects of eplerenone. Eplerenone selectively binds to recombinant human mineralocorticoid receptors relative to its binding to recombinant human glucocorticoid, progesterone and androgen receptors [1]. Benefits of eplerenone therapy over placebo were also observed in several secondary outcomes, including: death from any cause or hospitalization for HF; death from any cause; hospitalization for any reason; or hospitalization for HF [2].

Name	eplerenone
Synonym	More Synonyms

Description	Eplerenone is an aldosterone antagonist with an IC50 of 0.36 μM.Target: Mineralocorticoid ReceptorEplerenone is a selective mineralocorticoid receptor antagonist, which has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion. The resulting increased plasma renin activity and aldosterone circulating levels do not overcome the effects of eplerenone. Eplerenone selectively binds to recombinant human mineralocorticoid receptors relative to its binding to recombinant human glucocorticoid, progesterone and androgen receptors [1]. Benefits of eplerenone therapy over placebo were also observed in several secondary outcomes, including: death from any cause or hospitalization for HF; death from any cause; hospitalization for any reason; or hospitalization for HF [2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Mineralocorticoid Receptor Research Areas >> Cardiovascular Disease
References	[1]. Chatterjee, S., et al., Eplerenone is not superior to older and less expensive aldosterone antagonists. Am J Med, 2012. 125(8): p. 817-25. [2]. Dhillon, S., Eplerenone: a review of its use in patients with chronic systolic heart failure and mild symptoms. Drugs, 2013. 73(13): p. 1451-62.

Description

Related Catalog

Signaling Pathways >> Metabolic Enzyme/Protease >> Mineralocorticoid Receptor

Research Areas >> Cardiovascular Disease

References

[1]. Chatterjee, S., et al., Eplerenone is not superior to older and less expensive aldosterone antagonists. Am J Med, 2012. 125(8): p. 817-25.

[2]. Dhillon, S., Eplerenone: a review of its use in patients with chronic systolic heart failure and mild symptoms. Drugs, 2013. 73(13): p. 1451-62.

Density	1.3±0.1 g/cm3
Boiling Point	597.9±50.0 °C at 760 mmHg
Melting Point	241-243ºC
Molecular Formula	C₂₄H₃₀O₆
Molecular Weight	414.491
Flash Point	259.5±30.2 °C
Exact Mass	414.204254
PSA	82.20000
LogP	1.05
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.587

Eplerenone MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	3077
HS Code	29322090

Precursor 6
CAS#:95716-70-4 9,11-Eplerenone CAS#:67-56-1 Methanol CAS#:192704-54-4 4'S(4'α),7'α-he... CAS#:124-41-4 Sodium Methylate
CAS#:192569-17-8 11α-Hydroxy Can... CAS#:95716-71-5 delta-9,11-Canrenone
DownStream 0

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Methyl-(4aS,4bR,5aR,6aS,7R,9aS,9bR,10R)-4a,6a-dimethyl-2,5'-dioxo-2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-3H,3'H-spiro[cyclopenta[7,8]phenanthro[4b,5-b]oxiren-7,2'-furan]-10-carboxylat

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Methyl (4aS,4bR,5aR,6aS,7R,9aS,9bR,10R)-4a,6a-dimethyl-2,5'-dioxo-2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-3H,3'H-spiro[cyclopenta[7,8]phenanthro[4b,5-b]oxirene-7,2'-furan]-10-carboxylate

Elperenone

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epoxymexrenone

Eplerenone

spiro[cyclopenta[7,8]phenanthro[4b,5-b]oxirene-7(3H),2'(3'H)-furan]-10-carboxylic acid, 2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-4a,6a-dimethyl-2,5'-dioxo-, methyl ester, (4aS,4bR,5aR,6aS,7

Spiro[cyclopenta[7,8]phenanthro[4b,5-b]oxirene-7(3H),2'(3'H)-furan]-10-carboxylic acid, 2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-4a,6a-dimethyl-2,5'-dioxo-, methyl ester, (4aS,4bR,5aR,6aS,7R,9aS,9bR,10R)-

Methyl (4aS,4bR,5aR,7R,9aS,9bR,10R)-4a,6a-dimethyl-2,5'-dioxo-2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-3H,3'H-spiro[cyclopenta[7,8]phenanthro[4b,5-b]oxirene-7,2'-furan]-10-carboxylate

9,11α-Epoxy-17-hydroxy-3-oxo-17α-pregn-4-ene-7α,21-dicarboxylic Acid γ-Lactone Methyl Ester

EPLERINONE

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China
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