Maleic anhydride

Names

[ CAS No. ]:
108-31-6

[ Name ]:
Maleic anhydride

[Synonym ]:
Toxilic anhydride
BM-10
MFCD00005518
Maleic
Maleic anhydride
EINECS 203-571-6
dihydro-2,5-dioxofuran
2,5-Furandione
Furan-2,5-Dione
maleic acid anhydride
mala
MAN
Lytron 820

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
202.0±0.0 °C at 760 mmHg

[ Melting Point ]:
51-56 °C(lit.)

[ Molecular Formula ]:
C₄H₂O₃

[ Molecular Weight ]:
98.057

[ Flash Point ]:
103.3±0.0 °C

[ Exact Mass ]:
98.000397

[ PSA ]:
43.37000

[ LogP ]:
-0.37

[ Vapour density ]:
3.4 (vs air)

[ Vapour Pressure ]:
0.3±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.515

[ Stability ]:
Stable. Combustible. Incompatible with water, strong oxidizing agents, alkali metals, strong bases, amines, most common metals, polymerization catalysts and accelerators.

[ Water Solubility ]:
79 g/100 mL (25 ºC)

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ON3675000

CHEMICAL NAME :: Maleic anhydride

CAS REGISTRY NUMBER :: 108-31-6

BEILSTEIN REFERENCE NO. :: 0106909

LAST UPDATED :: 199712

DATA ITEMS CITED :: 44

MOLECULAR FORMULA :: C4-H2-O3

MOLECULAR WEIGHT :: 98.06

WISWESSER LINE NOTATION :: T5VOVJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 97 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 465 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 875 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2620 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 390 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: >20 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9800 ug/m3/6H/26W-I

TOXIC EFFECTS :: Blood - changes in spleen Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1220 mg/kg/61W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 4060 mg/kg

SEX/DURATION :: multigenerations

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Lung

REFERENCE :: GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971- Volume(issue)/page/year: 27,95,1981 *** REVIEWS *** ACGIH TLV-TWA 1.0 mg/m3 (0.25 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW 85CVA2 "Oncology 1970, Proceedings of the Tenth International Cancer Congress," Chicago, Year Book Medical Pub., 1971 Volume(issue)/page/year: 5,250,1970 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 0.25 ppm (1 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,148,1971 OSHA PEL (Gen Indu):8H TWA 0.25 ppm (1 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 0.25 ppm CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 0.25 ppm CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 0.25 ppm (1 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.25 ppm (1 mg/m3) JAN 1993 OEL-BELGIUM:TWA 0.25 ppm (1 mg/m3) JAN 1993 OEL-DENMARK:TWA 0.2 ppm (0.8 mg/m3) JAN 1993 OEL-FINLAND:TWA 0.25 ppm (1 mg/m3);STEL 0.75 ppm (3 mg/m3);Skin JAN 1993 OEL-FRANCE:STEL 1 mg/m3 JAN 1993 OEL-GERMANY:TWA 0.2 ppm (0.8 mg/m3) JAN 1993 OEL-HUNGARY:TWA 1 mg/m3;STEL 2 mg/m3 JAN 1993 OEL-THE NETHERLANDS:TWA 0.25 ppm (1 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 0.25 ppm (1 mg/m3) JAN 1993 OEL-RUSSIA:STEL 1 mg/m3 JAN 1993 OEL-SWEDEN:TWA 0.3 ppm (1.2 mg/m3);STEL 0.6 ppm (2.5 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 0.2 ppm (0.8 mg/m3);STEL 0.4 ppm (1.6 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 0.25 ppm (1 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO MALEIC ANHYDRIDE-air:10H TWA 0.25 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 43660 No. of Facilities: 5310 (estimated) No. of Industries: 51 No. of Occupations: 69 No. of Employees: 71386 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 43660 No. of Facilities: 5924 (estimated) No. of Industries: 65 No. of Occupations: 69 No. of Employees: 81551 (estimated) No. of Female Employees: 14807 (estimated)

Safety Information

[ Symbol ]:

GHS05, GHS07, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H314-H317-H334-H372-H373

[ Supplemental HS ]:
Corrosive to the respiratory tract.

[ Precautionary Statements ]:
P261-P280-P284-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338-P342 + P311

[ Target Organs ]:
Kidney, Respiratory system

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
C:Corrosive

[ Risk Phrases ]:
R22;R34;R42/43

[ Safety Phrases ]:
S22-S26-S36/37/39-S45

[ RIDADR ]:
UN 2215 8/PG 3

[ WGK Germany ]:
1

[ RTECS ]:
ON3675000

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
2917140000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

n-Butane
benzene
3-(butylcarbamoyl)prop-2-enoic acid
Furfural
fumaric acid
Phenol
3-Chloro-3,4-dihydro-2,5-furandione
MALEIC ACID
Crotonic acid
cyclohexane

DownStream

4-[2-chloro-N-(2-cyanoethyl)anilino]-4-oxobut-2-enoic acid
4-[4-(4-fluorophenoxy)phenyl]-4-oxobut-2-enoic acid
1-(4-TERT-BUTYL-PHENYL)-PYRROLE-2,5-DIONE
4-(6-methylnapthalen-2-yl)-4-oxobut-2-enoc acid
meso-2,3-Dibromosuccinic acid
(±)-2,3-Dibromosuccinic acid
2-[3-METHYL-2-(METHYLIMINO)-4-OXO-1,3-THIAZOLAN-5-YL]ACETIC ACID
(Z)-4-Amino-4-oxobut-2-enoic acid
5-Maleimidovaleric acid
N-Succinimidyl 3-maleimidopropionate

Customs

[ HS Code ]: 2917140000

[ Summary ]:
2917140000 furan-2,5-dione。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。Lowest tariff:6.5%。General tariff:30.0%

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1-(4,6-Dimethylpyrimidin-2-yl)-4-methanesulfonyl-1,4-diazepane
1-(Benzo[d][1,3]dioxol-5-yl)-3-(1-benzoyl-1,2,3,4-tetrahydroquinolin-7-yl)urea
N1-phenethyl-N2-((1-(thiophen-2-yl)cyclopropyl)methyl)oxalamide
5-(((1-phenyl-1H-imidazol-2-yl)thio)methyl)-3-(m-tolyl)-1,2,4-oxadiazole
1-(1-Benzoyl-1,2,3,4-tetrahydroquinolin-7-yl)-3-(2-methoxyphenyl)urea
3,6-dichloro-N-[3-(4-pyrimidin-2-ylpiperazin-1-yl)propyl]pyridine-2-carboxamide
N-cyclopropyl-1-(2-phenylethenesulfonyl)-N-[(pyridin-3-yl)methyl]piperidine-4-carboxamide
3-{1-[5-chloro-2-(methylsulfanyl)pyrimidine-4-carbonyl]-1,2,3,6-tetrahydropyridin-4-yl}-5-methoxy-1H-indole
1-(1-Benzoyl-1,2,3,4-tetrahydroquinolin-7-yl)-3-(2-ethoxyphenyl)urea

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