Maleic anhydride

Modify Date: 2026-07-01 00:09:53

Maleic anhydride Structure
Maleic anhydride structure
 Common Name Maleic anhydride
CAS Number 108-31-6 Molecular Weight 98.057
Density 1.5±0.1 g/cm3 Boiling Point 202.0±0.0 °C at 760 mmHg
Molecular Formula C4H2O3 Melting Point 51-56 °C(lit.)
MSDS Chinese USA Flash Point 103.3±0.0 °C
Symbol GHS05 GHS07 GHS08
GHS05, GHS07, GHS08		 Signal Word Danger

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name maleic anhydride
Synonym More Synonyms

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 1.5±0.1 g/cm3
Boiling Point 202.0±0.0 °C at 760 mmHg
Melting Point 51-56 °C(lit.)
Molecular Formula C4H2O3
Molecular Weight 98.057
Flash Point 103.3±0.0 °C
Exact Mass 98.000397
PSA 43.37000
LogP -0.37
Vapour density 3.4 (vs air)
Vapour Pressure 0.3±0.4 mmHg at 25°C
Index of Refraction 1.515
InChIKey FPYJFEHAWHCUMM-UHFFFAOYSA-N
SMILES O=C1C=CC(=O)O1
Stability Stable. Combustible. Incompatible with water, strong oxidizing agents, alkali metals, strong bases, amines, most common metals, polymerization catalysts and accelerators.
Water Solubility 79 g/100 mL (25 ºC)

 MSDS

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

 Toxicological Information

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
ON3675000
CHEMICAL NAME :
Maleic anhydride
CAS REGISTRY NUMBER :
108-31-6
BEILSTEIN REFERENCE NO. :
0106909
LAST UPDATED :
199712
DATA ITEMS CITED :
44
MOLECULAR FORMULA :
C4-H2-O3
MOLECULAR WEIGHT :
98.06
WISWESSER LINE NOTATION :
T5VOVJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
97 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
465 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
875 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
2620 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
390 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
>20 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
9800 ug/m3/6H/26W-I
TOXIC EFFECTS :
Blood - changes in spleen Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1220 mg/kg/61W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
4060 mg/kg
SEX/DURATION :
multigenerations
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Rodent - hamster Lung
REFERENCE :
GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971- Volume(issue)/page/year: 27,95,1981 *** REVIEWS *** ACGIH TLV-TWA 1.0 mg/m3 (0.25 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW 85CVA2 "Oncology 1970, Proceedings of the Tenth International Cancer Congress," Chicago, Year Book Medical Pub., 1971 Volume(issue)/page/year: 5,250,1970 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 0.25 ppm (1 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,148,1971 OSHA PEL (Gen Indu):8H TWA 0.25 ppm (1 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 0.25 ppm CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 0.25 ppm CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 0.25 ppm (1 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.25 ppm (1 mg/m3) JAN 1993 OEL-BELGIUM:TWA 0.25 ppm (1 mg/m3) JAN 1993 OEL-DENMARK:TWA 0.2 ppm (0.8 mg/m3) JAN 1993 OEL-FINLAND:TWA 0.25 ppm (1 mg/m3);STEL 0.75 ppm (3 mg/m3);Skin JAN 1993 OEL-FRANCE:STEL 1 mg/m3 JAN 1993 OEL-GERMANY:TWA 0.2 ppm (0.8 mg/m3) JAN 1993 OEL-HUNGARY:TWA 1 mg/m3;STEL 2 mg/m3 JAN 1993 OEL-THE NETHERLANDS:TWA 0.25 ppm (1 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 0.25 ppm (1 mg/m3) JAN 1993 OEL-RUSSIA:STEL 1 mg/m3 JAN 1993 OEL-SWEDEN:TWA 0.3 ppm (1.2 mg/m3);STEL 0.6 ppm (2.5 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 0.2 ppm (0.8 mg/m3);STEL 0.4 ppm (1.6 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 0.25 ppm (1 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO MALEIC ANHYDRIDE-air:10H TWA 0.25 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 43660 No. of Facilities: 5310 (estimated) No. of Industries: 51 No. of Occupations: 69 No. of Employees: 71386 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 43660 No. of Facilities: 5924 (estimated) No. of Industries: 65 No. of Occupations: 69 No. of Employees: 81551 (estimated) No. of Female Employees: 14807 (estimated)

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol GHS05 GHS07 GHS08
GHS05, GHS07, GHS08
Signal Word Danger
Hazard Statements H302-H314-H317-H334-H372-H373
Supplemental HS Corrosive to the respiratory tract.
Precautionary Statements P261-P280-P284-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338-P342 + P311
Target Organs Kidney, Respiratory system
Personal Protective Equipment Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes C:Corrosive
Risk Phrases R22;R34;R42/43
Safety Phrases S22-S26-S36/37/39-S45
RIDADR UN 2215 8/PG 3
WGK Germany 1
RTECS ON3675000
Packaging Group III
Hazard Class 8
HS Code 2917140000

 Synthetic Route

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

 Customs

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code 2917140000
Summary 2917140000 furan-2,5-dione。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。Lowest tariff:6.5%。General tariff:30.0%

 Articles28

More Articles

This table lists relevant public references with title, journal and publication metadata for this compound.

An Oligonucleotide Transfection Vector Based on HSA and PDMAEMA Conjugation: Effect of Polymer Molecular Weight on Cell Proliferation and on Multicellular Tumor Spheroids.

Macromol. Biosci. 15 , 965-78, (2015)

A novel gene transfection vector was fabricated based on the conjugation of human serum albumin (HSA) and maleimide end functionalized poly[(N,N-dimethylamino) ethyl methacrylate] (PDMAEMA). The bioco...

Extracellular matrix deposition of bone marrow stroma enhanced by macromolecular crowding.

Biomaterials 73 , 60-9, (2015)

Decellularized extracellular matrices (ECM) from in vitro cell cultures can serve as in vivo-like matrix scaffolds for modulating cell-ECM interactions. Macromolecular crowding (MMC), the supplementat...

Self-cleaning Metal Organic Framework (MOF) based ultra filtration membranes--a solution to bio-fouling in membrane separation processes.

Sci. Rep. 4 , 6555, (2014)

Bio-fouling is a serious problem in many membrane-based separation processes for water and wastewater treatment. Current state of the art methods to overcome this are to modify the membranes with eith...

 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

Toxilic anhydride
BM-10
MFCD00005518
Maleic
Maleic anhydride
EINECS 203-571-6
dihydro-2,5-dioxofuran
2,5-Furandione
Furan-2,5-Dione
maleic acid anhydride
mala
MAN
Lytron 820

 Maleic anhydride | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the InChIKey of maleic anhydride?
A: InChIKey of maleic anhydride is FPYJFEHAWHCUMM-UHFFFAOYSA-N.
Q: What is the LogP of maleic anhydride?
A: LogP of maleic anhydride is -0.37.
Q: How is the water solubility of maleic anhydride?
A: Water solubility of maleic anhydride: 79 g/100 mL (25 ºC).
Q: What is the polar surface area (PSA) of maleic anhydride?
A: Polar surface area (PSA) of maleic anhydride is 43.37000.
Q: What is the safety information for maleic anhydride?
A: Safety information for maleic anhydride: S22-S26-S36/37/39-S45.
Q: What English synonyms does maleic anhydride have?
A: English synonyms of maleic anhydride: Toxilic anhydride, BM-10, MFCD00005518, Maleic, Maleic anhydride, EINECS 203-571-6, dihydro-2,5-dioxofuran, 2,5-Furandione, Furan-2,5-Dione, maleic acid anhydride, mala, MAN, Lytron 820.
Q: What is the SMILES notation of maleic anhydride?
A: SMILES notation of maleic anhydride is O=C1C=CC(=O)O1.
Q: What is the boiling point of maleic anhydride?
A: Boiling point of maleic anhydride is 202.0±0.0 °C at 760 mmHg.
Q: What are the upstream materials of maleic anhydride?
A: Related upstream materials(CAS) of maleic anhydride: 106-97-8;71-43-2;45019-30-5;98-01-1;110-17-8;108-95-2;1192-71-8;6915-18-0;3724-65-0;110-82-7.
Q: What is the English name of maleic anhydride?
A: The English name of maleic anhydride is maleic anhydride.

 Maleic anhydridefactory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
Dayang Chem (Hangzhou) Co., Ltd.
Henan Tianfu Chemical Co., Ltd.
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Chemsrc provides Maleic anhydride(CAS#:108-31-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Maleic anhydride are included as well.>> amp version: Maleic anhydride

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