GSK2126458(GSK458)

Suppliers

Names

[ Name ]:
GSK2126458(GSK458)

[Synonym ]:
2,4-difluoro-N-(2-methoxy-5-(4-(pyridazin-4-yl)quinolin-6-yl)pyridin-3-yl)benzenesulfonamide
2,4-Difluoro-N-{2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl}benzenesulfonamide
GSK2126458
Omipalisib
gsk2126458 (gsk458)
2,4-difluoro-N-[2-methoxy-5-(4-pyridazin-4-ylquinolin-6-yl)pyridin-3-yl]benzenesulfonamide
GSK 2126458
gsk-212
Benzenesulfonamide, 2,4-difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]-
GSK458

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
715.6±70.0 °C at 760 mmHg

[ Melting Point ]:
187-189℃

[ Molecular Formula ]:
C₂₅H₁₇F₂N₅O₃S

[ Molecular Weight ]:
505.496

[ Flash Point ]:
386.6±35.7 °C

[ Exact Mass ]:
505.102020

[ PSA ]:
115.34000

[ LogP ]:
3.81

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.660

[ Storage condition ]:
-20℃

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

N-(5-Bromo-2-methoxypyridin-3-yl)-2,4-difluorobenzenesulfonamide
6-Bromo-4-(4-pyridazinyl)quinoline
3-Amino-5-bromo-2-methoxypyridine
5-Bromo-2-chloro-3-nitropyridine
5-Bromo-2-methoxy-3-nitropyridine
5-bromo-3-nitropyridin-2-ol
6-Bromo-4-chloroquinoline
6-Bromo-4-iodoquinoline
6-bromo-4-chloroquinoline (Hydrochloride)
6-Bromoquinolin-4-ol