methylpiperazine

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Names

[ CAS No. ]:
109-01-3

[ Name ]:
methylpiperazine

[Synonym ]:
Piperazine, 1-methyl-
methyl piperazine
4-Methylpiperazine
Cyclizine Related Compound A
N-METHYL-PIPERAZINE
EINECS 203-639-5
N-Methylpiperazine
PIPERAZINE,1-METHYL
N'-Methylpiperazine
1-Methyl-piperazine
1-Methylpiperazine
MFCD00005966
methylpiperazine
N-METHYL PIPERAZINE

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
138.0±8.0 °C at 760 mmHg

[ Melting Point ]:
-6 °C

[ Molecular Formula ]:
C5H12N2

[ Molecular Weight ]:
100.162

[ Flash Point ]:
42.2±0.0 °C

[ Exact Mass ]:
100.100044

[ PSA ]:
15.27000

[ LogP ]:
-0.18

[ Vapour density ]:
3.5 (vs air)

[ Vapour Pressure ]:
6.9±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.442

[ Storage condition ]:
Store under Nitrogen

[ Water Solubility ]:
soluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TM1225000
CHEMICAL NAME :
Piperazine, 1-methyl-
CAS REGISTRY NUMBER :
109-01-3
BEILSTEIN REFERENCE NO. :
0102724
LAST UPDATED :
199701
DATA ITEMS CITED :
10
MOLECULAR FORMULA :
C5-H12-N2
MOLECULAR WEIGHT :
100.19
WISWESSER LINE NOTATION :
T6M DNTJ D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Open irritation test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 23,95,1962
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,863,1986
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,863,1986 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2830 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 23,95,1962
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1450 mg/kg
TOXIC EFFECTS :
Behavioral - excitement Behavioral - changes in motor activity (specific assay) Behavioral - muscle contraction or spasticity
REFERENCE :
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 15,116,1979
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2740 mg/m3/2H
TOXIC EFFECTS :
Behavioral - excitement Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 11,123,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD691-490
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1490 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 23,95,1962 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
15040 mg/kg/32D-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 11,123,1969

Safety Information

[ Symbol ]:

GHS02, GHS05, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H226-H312-H314-H331

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
C:Corrosive

[ Risk Phrases ]:
R10;R21;R34

[ Safety Phrases ]:
S16-S26-S36/37/39-S45

[ RIDADR ]:
UN 2734 8/PG 2

[ WGK Germany ]:
2

[ RTECS ]:
TM1225000

[ Packaging Group ]:
III

[ Hazard Class ]:
3

[ HS Code ]:
2933599090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • dea
  • methylamine
  • 2-nitro-(N-methylpiperazinyl)phenylsulphonamide
  • Piperazine
  • Dimethyl Carbonate
  • Piperazine,1-methyl-4-nitroso-
  • 1-Benzenesulfonyl-4-methyl-piperazine
  • N-Methyldiethanolamine
  • 1-Benzyl-4-methylpiperazine

DownStream

  • 3'-Hydroxy-5'-(4-methyl-piperazin-1-yl)benzoxazinorifamycin
  • ethyl 6-fluoro-1-(4-fluorophenyl)-7-(4-methylpiperazin-1-yl)-4-oxo-1,8-naphthyridine-3-carboxylate
  • 1-Piperazinepropionamidoxime,4-methyl-(6CI)
  • [4-methoxy-2-[4-(4-methylpiperazin-1-yl)-4-oxo-1-phenylbutyl]phenyl] acetate
  • 2-Acetyl-10-[3-(4-methylpiperazino)propyl]-10H-phenothiazine
  • 1-(3-chloro-4-nitrophenyl)-4-methylpiperazine
  • 1-Piperazinepropanol,-bta-,4-dimethyl-(6CI)
  • 1-((3-Bromo-4-ethoxyphenyl)sulfonyl)-4-methylpiperazine
  • 4-(4-Methyl-1-piperazinyl)-1-butanol
  • 3-(4-METHYLPIPERAZIN-1-YL)PROPANOIC ACID

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Related Compounds

  • N-methylpiperazine
  • 2-Methylpiperazine
  • N-methylpiperazine
  • 2-Methylpiperazine
  • 2-Methylpiperazine-d7
  • 1-(H)Methylpiperazine
  • 10,10'-(2,8-Dimethylphenoxathiine-4,6-diyl)bis(2,8-dimethyl-10H-phenoxaphosphinine)
  • 2-(1-methyl-1H-pyrazol-4-yl)pyrimidine-4-carboxylic acid
  • Cyclohexaneacetic acid, 3-ethyl-1-hydroxy-I+/--(1-methylethyl)-
  • Pyrimidine, 4-chloro-6-[(3-ethylcyclohexyl)oxy]-5-(1-methylethyl)-
  • 1-[(4-Chlorophenyl)methyl]-4,6-dimethylindol-5-amine
  • Methyl 1-(2-chloroethyl)-4-(1,3-dioxolan-2-yl)cyclohexanecarboxylate
  • 4-Methyl-2-(1-methyl-1h-pyrazol-3-yl)pyrimidine-5-carboxylic acid
  • 4-methyl-2-(1-methyl-1H-pyrazol-4-yl)pyrimidine-5-carboxylic acid
  • 6-(Dimethoxymethyl)pyridine-3-carboxylic acid
  • 5-Methylheptane-3-sulfonyl chloride