TMEDA

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Names

[ CAS No. ]:
110-18-9

[ Name ]:
TMEDA

[Synonym ]:
N,N,N′,N′ tetramethylethylenediamine
Tetrameen
N,N,N‘,N‘-Tetramethylethylenediamine,purified by redistillation,AcroSeal
EINECS 203-744-6
N,N,N',N'-Tetramethylethylenediamine
N,N,N`,N`-Tetramethylethylenediamine
1,2-Bis(dimethylamino)ethane,TEMED,TMEDA
Kaolizer 11
1,2-Bis(dimethylamino)ethane
N,N,N,N-Tetramethylethylenediamine
tetramethyldiaminoethane
N,N,N′,N′-tetramethyl-1,2-ethanediamine
N,N,N′,N′-tetramethylethylenediamine
Dabco TMEDA
n,n,n',n'-tetramethylethane-1,2-diamine
TEMED
1,2-Ethanediamine, N,N,N,N-tetramethyl-
Propamine D
N,N′-tetramethylethylenediamine
TMEDA
N,N,N',N'-tetramethyl-1,2-diaminoethane
Toyocat TE
N1,N1,N2,N2-Tetramethylethane-1,2-diamine
N,N,N',N'-Tetramethyl-1,2-ethanediamine
N,N,N′,N′-tetramethyl-1,2-diaminoethane
N,N,N‘,N‘-Tetramethylethylenediamine
ZnCl2*N,N,N,N-tetramethylethylenediamine
N,N,N‘,N‘-Tetramet
TMED
MFCD00008335

Chemical & Physical Properties

[ Density]:
0.8±0.1 g/cm3

[ Boiling Point ]:
121.0±0.0 °C at 760 mmHg

[ Melting Point ]:
−55 °C(lit.)

[ Molecular Formula ]:
C₆H₁₆N₂

[ Molecular Weight ]:
116.205

[ Flash Point ]:
10.0±0.0 °C

[ Exact Mass ]:
116.131348

[ PSA ]:
6.48000

[ LogP ]:
0.30

[ Vapour Pressure ]:
14.9±0.2 mmHg at 25°C

[ Index of Refraction ]:
1.438

[ Stability ]:
Stable. Highly flammable. Incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides, copper, mercury.

[ Water Solubility ]:
miscible

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KV7175000

CHEMICAL NAME :: Ethylenediamine, N,N,N',N'-tetramethyl-

CAS REGISTRY NUMBER :: 110-18-9

LAST UPDATED :: 199710

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C6-H16-N2

MOLECULAR WEIGHT :: 116.24

WISWESSER LINE NOTATION :: 1N1&2N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 30,63,1948

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 29,1363,1946 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 268 mg/kg

TOXIC EFFECTS :: Brain and Coverings - other degenerative changes Spinal Cord - other degenerative changes

REFERENCE :: TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 15,19,1995

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1318 ppm/4H

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - ataxia Behavioral - irritability

REFERENCE :: TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 8,249,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 630 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 28(6),55,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 5390 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 30,470,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1230 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 15,19,1995

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: >316 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977- Volume(issue)/page/year: 6,149,1982 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 ppm/6H/11D-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Endocrine - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0536165 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1174 No. of Facilities: 33 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 66 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - A1174 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 28 (estimated)

Safety Information

[ Symbol ]:

GHS02, GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H302-H314-H332

[ Precautionary Statements ]:
P210-P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
C:Corrosive

[ Risk Phrases ]:
R11;R20/22;R34

[ Safety Phrases ]:
S16-S26-S36/37/39-S45

[ RIDADR ]:
UN 2372 3/PG 2

[ WGK Germany ]:
1

[ RTECS ]:
KV7175000

[ Packaging Group ]:
II

[ Hazard Class ]:
3

[ HS Code ]:
2921219000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

N,N,N',N'-tetramethyloxamide
Dimethylamine
1,2-Dibromoethane
Methanol
1,2-Ethanediamine
Acrylonitrile
Formaldehyde
2-Methylaminoethanol
(tetramethylethylenediamine)lithium trihydro(2,4,6-tri-tert-butylphenyl)borate
[CpFe(COD)][Li(tmeda)]

DownStream

N,N'-Dimethylpiperazine
pentamethyldiethylenetriamine
2-(N-ethylmethylamino)ethyldimethylamine
Trimethylamine
1-(2-dimethylaminoethyl)-4-methylpiperazine
N,N-dimethyl-1-trimethylstannylethenamine
N,N,N'-trimethyl-N'-(trimethylstannylmethyl)ethane-1,2-diamine
trans-1-(dimethylamino)-2-(trimethylstannyl)ethene
Hexamethyldistannane
(dimethylamino)trimethyltin

Customs

[ HS Code ]: 2921290000

[ Summary ]:
2921290000 other acyclic polyamines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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