putrescine

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Names

[ CAS No. ]:
110-60-1

[ Name ]:
putrescine

[Synonym ]:
1,4-DIAMINOBUTAN
butane-1.4-diamine
Tetramethylenediamine
1,4-Butanediamine
1,4-butylenediamine
Putrescine, free base
Butan-1,4-diamin
Butane-1,4-diamine
putrescine
EINECS 203-782-3
MFCD00008235
1,4-Diaminobutane

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
159.0±8.0 °C at 760 mmHg

[ Melting Point ]:
27 °C

[ Molecular Formula ]:
C₄H₁₂N₂

[ Molecular Weight ]:
88.151

[ Flash Point ]:
51.7±0.0 °C

[ Exact Mass ]:
88.100044

[ PSA ]:
52.04000

[ LogP ]:
-0.72

[ Vapour Pressure ]:
2.6±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.455

[ Stability ]:
Stable. Incompatible with acids, acid chlorides, acid anhydrides, strong oxidizing agents. Flammable.

[ Water Solubility ]:
cell culture medium: 0.16 mg/mL

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EJ6800000

CHEMICAL NAME :: 1,4-Butanediamine

CAS REGISTRY NUMBER :: 110-60-1

BEILSTEIN REFERENCE NO. :: 0605282

LAST UPDATED :: 199712

DATA ITEMS CITED :: 16

MOLECULAR FORMULA :: C4-H12-N2

MOLECULAR WEIGHT :: 88.18

WISWESSER LINE NOTATION :: Z4Z

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 463 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Sense Organs and Special Senses (Eye) - ptosis Kidney, Ureter, Bladder - other changes in urine composition

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1750 mg/kg

TOXIC EFFECTS :: Behavioral - muscle contraction or spasticity Vascular - BP lowering not characterized in autonomic section

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1576 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Kidney, Ureter, Bladder - other changes in urine composition Skin and Appendages - dermatitis, other (after systemic exposure)

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Rectal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 314 mg/kg

SEX/DURATION :: female 12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - other effects to embryo Reproductive - Specific Developmental Abnormalities - musculoskeletal system

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - mouse Liver

DOSE/DURATION :: 20 mmol/L

REFERENCE :: AMOKAG Acta Medicia Okayama. (Okayama Univ. Medical School, Okayama, Japan) V.27 1973- Volume(issue)/page/year: 33,149,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4958 No. of Facilities: 3 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 3 (estimated) No. of Female Employees: 3 (estimated)

Safety Information

[ Symbol ]:

GHS02, GHS05, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H226-H302-H311-H314-H330

[ Precautionary Statements ]:
P210-P280-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338-P370 + P378

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
C:Corrosive

[ Risk Phrases ]:
R20/21/22;R34

[ Safety Phrases ]:
S16-S26-S36/37/39-S45

[ RIDADR ]:
UN 2928 6.1/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
EJ6800000

[ Packaging Group ]:
II

[ Hazard Class ]:
8

[ HS Code ]:
2921290000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

4-Amino-1-butanol
Butanedial, 2,3-dioxime
1,4-Butanediol
4-Aminobutyronitrile
Succinonitrile
butane-1,4-diamine,sulfuric acid
Pyridazine
1,4-dichloro-1,4-dinitro-buta-1,3-diene
N-carbamoylputrescine

DownStream

methylamine
N-benzylputrescine
N-[4-(benzoylcarbamothioylamino)butylcarbamothioyl]benzamide
N,N'-di(quinolin-4-yl)butane-1,4-diamine
N,N'-BIS(SALICYLIDENE)-1,4-BUTANEDIAMINE
1,4-BUTANE DIISOTHIOCYANATE
Arcaine sulfate
1,4-Diisocyanatobutane
mono-trityl 1,4-diaminobutane acetic acid salt
Glycine,N,N'-1,4-butanediylbis[N-(carboxymethyl)-

Customs

[ HS Code ]: 2921290000

[ Summary ]:
2921290000 other acyclic polyamines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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