putrescine

Modify Date: 2024-01-02 23:15:20

putrescine structure	Common Name	putrescine
	CAS Number	110-60-1	Molecular Weight	88.151
	Density	0.9±0.1 g/cm3	Boiling Point	159.0±8.0 °C at 760 mmHg
	Molecular Formula	C₄H₁₂N₂	Melting Point	27 °C
	MSDS	Chinese USA	Flash Point	51.7±0.0 °C
	Symbol	GHS02, GHS05, GHS06	Signal Word	Danger

Use of putrescine

1,4-Butanediamine is an indicator of pollution-induced stress in higher plants: barley and rape stressed with Cr(III) or Cr(VI). 1,4-Butanediamine is an important source of GABA.

Name	putrescine
Synonym	More Synonyms

Description	1,4-Butanediamine is an indicator of pollution-induced stress in higher plants: barley and rape stressed with Cr(III) or Cr(VI). 1,4-Butanediamine is an important source of GABA.
Related Catalog	Natural Products >> Others Research Areas >> Others
Target	Human Endogenous Metabolite
In Vitro	1,4-Butanediamine (Putrescine) is an important source of GABA in the postnatal rat subventricular zone. GABA synthesis from an alternative pathway uses 1,4-Butanediamine as a precursor.
References	[1]. Hauschild MZ. Putrescine (1,4-diaminobutane) as an indicator of pollution-induced stress in higher plants: barley and rape stressed with Cr(III) or Cr(VI). Ecotoxicol Environ Saf. 1993 Oct;26(2):228-47. [2]. Sequerra EB, et al. Putrescine as an important source of GABA in the postnatal rat subventricular zone. Neuroscience. 2007 May 11;146(2):489-93.

Density	0.9±0.1 g/cm3
Boiling Point	159.0±8.0 °C at 760 mmHg
Melting Point	27 °C
Molecular Formula	C₄H₁₂N₂
Molecular Weight	88.151
Flash Point	51.7±0.0 °C
Exact Mass	88.100044
PSA	52.04000
LogP	-0.72
Vapour Pressure	2.6±0.3 mmHg at 25°C
Index of Refraction	1.455
Stability	Stable. Incompatible with acids, acid chlorides, acid anhydrides, strong oxidizing agents. Flammable.
Water Solubility	cell culture medium: 0.16 mg/mL

putrescine MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EJ6800000

CHEMICAL NAME :: 1,4-Butanediamine

CAS REGISTRY NUMBER :: 110-60-1

BEILSTEIN REFERENCE NO. :: 0605282

LAST UPDATED :: 199712

DATA ITEMS CITED :: 16

MOLECULAR FORMULA :: C4-H12-N2

MOLECULAR WEIGHT :: 88.18

WISWESSER LINE NOTATION :: Z4Z

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 463 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Sense Organs and Special Senses (Eye) - ptosis Kidney, Ureter, Bladder - other changes in urine composition

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1750 mg/kg

TOXIC EFFECTS :: Behavioral - muscle contraction or spasticity Vascular - BP lowering not characterized in autonomic section

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1576 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Kidney, Ureter, Bladder - other changes in urine composition Skin and Appendages - dermatitis, other (after systemic exposure)

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Rectal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 314 mg/kg

SEX/DURATION :: female 12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - other effects to embryo Reproductive - Specific Developmental Abnormalities - musculoskeletal system

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - mouse Liver

DOSE/DURATION :: 20 mmol/L

REFERENCE :: AMOKAG Acta Medicia Okayama. (Okayama Univ. Medical School, Okayama, Japan) V.27 1973- Volume(issue)/page/year: 33,149,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4958 No. of Facilities: 3 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 3 (estimated) No. of Female Employees: 3 (estimated)

Symbol	GHS02, GHS05, GHS06
Signal Word	Danger
Hazard Statements	H226-H302-H311-H314-H330
Precautionary Statements	P210-P280-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338-P370 + P378
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	C:Corrosive
Risk Phrases	R20/21/22;R34
Safety Phrases	S16-S26-S36/37/39-S45
RIDADR	UN 2928 6.1/PG 2
WGK Germany	3
RTECS	EJ6800000
Packaging Group	II
Hazard Class	8
HS Code	2921290000

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HS Code	2921290000
Summary	2921290000 other acyclic polyamines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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1,4-DIAMINOBUTAN

butane-1.4-diamine

Tetramethylenediamine

1,4-Butanediamine

1,4-butylenediamine

Putrescine, free base

Butan-1,4-diamin

Butane-1,4-diamine

putrescine

EINECS 203-782-3

MFCD00008235

1,4-Diaminobutane

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putrescine

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