cyclohexane

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Names

[ CAS No. ]:
110-82-7

[ Name ]:
cyclohexane

[Synonym ]:
CYCLOHEXANE HPLC GRADE
HEXAMETHYLENE
HEXANAPHTHENE
MFCD00003814
Cyclohesan
NAPHTHENE
cyclo-hexane
cyclohexaan
hexamethylen
EINECS 203-806-2
Cyclohexane
Cicloesano
Cykloheksan
cyclohexan
Acrylates c10 30

Chemical & Physical Properties

[ Density]:
0.8±0.1 g/cm3

[ Boiling Point ]:
80.7±0.0 °C at 760 mmHg

[ Melting Point ]:
6.5ºC

[ Molecular Formula ]:
C₆H₁₂

[ Molecular Weight ]:
84.160

[ Flash Point ]:
-18.3±0.0 °C

[ Exact Mass ]:
84.093903

[ LogP ]:
3.39

[ Vapour density ]:
2.9 (vs air)

[ Vapour Pressure ]:
93.7±0.1 mmHg at 25°C

[ Index of Refraction ]:
1.433

[ Water Solubility ]:
PRACTICALLY INSOLUBLE

[ Freezing Point ]:
6.554℃

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GU6300000

CHEMICAL NAME :: Cyclohexane

CAS REGISTRY NUMBER :: 110-82-7

LAST UPDATED :: 199712

DATA ITEMS CITED :: 46

MOLECULAR FORMULA :: C6-H12

MOLECULAR WEIGHT :: 84.18

WISWESSER LINE NOTATION :: L6TJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 12705 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 813 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 70 gm/m3/2H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 5500 mg/kg

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 89600 mg/m3/1H

TOXIC EFFECTS :: Behavioral - general anesthetic Behavioral - tremor Behavioral - muscle contraction or spasticity

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >180 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 70 gm/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 300 ppm/6H/2W-I

TOXIC EFFECTS :: Brain and Coverings - other degenerative changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 15 gm/kg/2W-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes in urine composition

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 7444 ppm/6H/2W-I

TOXIC EFFECTS :: Autonomic Nervous System - other (direct) parasympathomimetic Gastrointestinal - hypermotility, diarrhea Related to Chronic Data - death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 9220 ppm/6H/5W-I

TOXIC EFFECTS :: Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - tremor Related to Chronic Data - death

MUTATION DATA

TYPE OF TEST :: DNA adduct

TEST SYSTEM :: Bacteria - Escherichia coli

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,95,1981 *** REVIEWS *** ACGIH TLV-TWA 1030 mg/m3 (300 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 300 ppm (1050 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,65,1971 OSHA PEL (Gen Indu):8H TWA 300 ppm (1050 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 300 ppm (1050 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 300 ppm (1050 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 300 ppm (1050 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 300 ppm (1050 mg/m3) JAN 1993 OEL-AUSTRIA:TWA 300 ppm (1050 mg/m3) JAN 1993 OEL-BELGIUM:TWA 300 ppm (1030 mg/m3) JAN 1993 OEL-DENMARK:TWA 300 ppm (1050 mg/m3) JAN 1993 OEL-FINLAND:TWA 300 ppm (1050 mg/m3);STEL 375 ppm (1315 mg/m3) JAN 1993 OEL-FRANCE:TWA 300 ppm (1050 mg/m3);STEL 375 ppm (1300 mg/m3) JAN 1993 OEL-GERMANY:TWA 300 ppm (1050 mg/m3) JAN 1993 OEL-HUNGARY:TWA 500 mg/m3;STEL 1000 mg/m3 JAN 1993 OEL-JAPAN:TWA 150 ppm (520 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 300 ppm (1050 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 300 ppm (1050 mg/m3) JAN 1993 OEL-POLAND:TWA 80 mg/m3 JAN 1993 OEL-RUSSIA:TWA 150 ppm;STEL 80 mg/m3 JAN 1993 OEL-SWEDEN:TWA 300 ppm (1000 mg/m3);STEL 370 ppm (1300 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 300 ppm (1050 mg/m3);STEL 600 ppm JAN 1993 OEL-TURKEY:TWA 300 ppm (1050 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 300 ppm (1050 mg/m3);STEL 375 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO CYCLOHEXANE-air:10H TWA 300 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 21190 No. of Facilities: 14841 (estimated) No. of Industries: 117 No. of Occupations: 74 No. of Employees: 125761 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 21190 No. of Facilities: 2260 (estimated) No. of Industries: 37 No. of Occupations: 54 No. of Employees: 55077 (estimated) No. of Female Employees: 14873 (estimated)

Safety Information

[ Symbol ]:

GHS02, GHS07, GHS08, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H304-H315-H336-H410

[ Precautionary Statements ]:
P210-P301 + P310-P331-P370 + P378-P403 + P235

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
F:Flammable

[ Risk Phrases ]:
R11;R38;R50/53;R65;R67

[ Safety Phrases ]:
S16-S25-S33-S60-S61-S62-S9

[ RIDADR ]:
UN 1145

[ WGK Germany ]:
2

[ RTECS ]:
GU6300000

[ Packaging Group ]:
II

[ Hazard Class ]:
3

[ HS Code ]:
2902110000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Phenol
Cyclohexene
cyclohexa-1,3-diene
Carbon dioxide
Cyclohexanone
1,2-Benzenediol
benzene
Guaiacol
Cyclohexanol

DownStream

2-methyl-2-(2-methylprop-1-enylideneamino)propanenitrile
4-Methylquinaldine
Quinoline, 2-methyl-,1-oxide
4-cyclohexyl-2-methylquinoline
Cyclohexanol
acetic acid,cyclohex-3-en-1-ol
1-cyclohexyl-1-hydroxyiminopropan-2-one
4-CHLOROPHENYL CYCLOHEXYL KETONE
5-Cyclohexylpentanoic acid
Succinonitrile

Customs

[ HS Code ]: 2902110000

[ Summary ]:
2902110000 cyclohexane。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:2.0%。general tariff:30.0%

Articles

A survey of dioxin-like contaminants in fish from recreational fishing.

Environ. Monit. Assess. 187 , 509, (2015)

The dioxin and dioxin-like compounds are regarded as one of the most toxic group of environmental contaminants. Food for the commercial market is regularly monitored for their dioxin levels and the co...

Preliminary study on brominated dioxins/furans and hydroxylated/methoxylated PBDEs in Baltic cod (Gadus morhua) liver. Comparison to the levels of analogue chlorinated co-occurring pollutants.

Mar. Pollut. Bull. 96 , 165-75, (2015)

Low pg levels of PBDD/Fs in 0.8-38.9 pg g(-1) (fat) range (mean 14.2 pg g(-1)) observed in the tested cod liver samples were significantly lower than levels of their chlorinated analogues (25.1-95.9 r...

Multi-element, multi-compound isotope profiling as a means to distinguish the geographical and varietal origin of fermented cocoa (Theobroma cacao L.) beans.

Food Chem. 188 , 576-82, (2015)

Multi-element stable isotope ratios have been assessed as a means to distinguish between fermented cocoa beans from different geographical and varietal origins. Isotope ratios and percentage compositi...

cyclohexane
Cyclohexane-d
Me-cyclohexane
Cyclohexanediol
CYCLOHEXANE-205
cyclohexane-d11
4-(aminomethyl)-N-(3-propan-2-yloxypropyl)pyridin-2-amine
3-chloro-N,4-dimethyl-5-sulfamoylbenzamide
Ethyl 2-amino-1,5-dimethyl-1h-pyrrole-3-carboxylate
Ethyl 5-((benzyloxy)methyl)-4-oxo-3-((2-(trimethylsilyl)ethoxy)methyl)-3,4-dihydroquinazoline-2-carboxylate
2-(Pyridin-4-ylmethoxy)pyridine-4-carbonitrile
2-([1,1'-Biphenyl]-4-ylmethoxy)-4-pyridinemethanamine
rac-(2R,3S)-1-[(benzyloxy)carbonyl]-2-phenylpyrrolidine-3-carboxylic acid
1'-(4-Nitro-2-trifluoromethyl-phenyl)-[1,4']bipiperidinyl
alpha-Pyrrolidinononanophenone
(3-Nitro-5-trifluoromethyl-phenyl)-(4-isopropylpiperazin-1-yl)-methanone

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