cyclohexane

MOLECULAR FORMULA :

C6-H12

MOLECULAR WEIGHT :

84.18

WISWESSER LINE NOTATION :

L6TJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rabbit

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

12705 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

813 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

70 gm/m3/2H

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

5500 mg/kg

TOXIC EFFECTS :

Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :

LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

89600 mg/m3/1H

TOXIC EFFECTS :

Behavioral - general anesthetic Behavioral - tremor Behavioral - muscle contraction or spasticity

TYPE OF TEST :

LD - Lethal dose

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

>180 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Mammal - species unspecified

DOSE/DURATION :

70 gm/m3

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

300 ppm/6H/2W-I

TOXIC EFFECTS :

Brain and Coverings - other degenerative changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

15 gm/kg/2W-I

TOXIC EFFECTS :

Kidney, Ureter, Bladder - other changes in urine composition

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

7444 ppm/6H/2W-I

TOXIC EFFECTS :

Autonomic Nervous System - other (direct) parasympathomimetic Gastrointestinal - hypermotility, diarrhea Related to Chronic Data - death

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

9220 ppm/6H/5W-I

TOXIC EFFECTS :

Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - tremor Related to Chronic Data - death

MUTATION DATA

TYPE OF TEST :

DNA adduct

TEST SYSTEM :

Bacteria - Escherichia coli

REFERENCE :

MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,95,1981 *** REVIEWS *** ACGIH TLV-TWA 1030 mg/m3 (300 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 300 ppm (1050 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,65,1971 OSHA PEL (Gen Indu):8H TWA 300 ppm (1050 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 300 ppm (1050 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 300 ppm (1050 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 300 ppm (1050 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 300 ppm (1050 mg/m3) JAN 1993 OEL-AUSTRIA:TWA 300 ppm (1050 mg/m3) JAN 1993 OEL-BELGIUM:TWA 300 ppm (1030 mg/m3) JAN 1993 OEL-DENMARK:TWA 300 ppm (1050 mg/m3) JAN 1993 OEL-FINLAND:TWA 300 ppm (1050 mg/m3);STEL 375 ppm (1315 mg/m3) JAN 1993 OEL-FRANCE:TWA 300 ppm (1050 mg/m3);STEL 375 ppm (1300 mg/m3) JAN 1993 OEL-GERMANY:TWA 300 ppm (1050 mg/m3) JAN 1993 OEL-HUNGARY:TWA 500 mg/m3;STEL 1000 mg/m3 JAN 1993 OEL-JAPAN:TWA 150 ppm (520 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 300 ppm (1050 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 300 ppm (1050 mg/m3) JAN 1993 OEL-POLAND:TWA 80 mg/m3 JAN 1993 OEL-RUSSIA:TWA 150 ppm;STEL 80 mg/m3 JAN 1993 OEL-SWEDEN:TWA 300 ppm (1000 mg/m3);STEL 370 ppm (1300 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 300 ppm (1050 mg/m3);STEL 600 ppm JAN 1993 OEL-TURKEY:TWA 300 ppm (1050 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 300 ppm (1050 mg/m3);STEL 375 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO CYCLOHEXANE-air:10H TWA 300 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 21190 No. of Facilities: 14841 (estimated) No. of Industries: 117 No. of Occupations: 74 No. of Employees: 125761 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 21190 No. of Facilities: 2260 (estimated) No. of Industries: 37 No. of Occupations: 54 No. of Employees: 55077 (estimated) No. of Female Employees: 14873 (estimated)