Piperazine

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Names

[ CAS No. ]:
110-85-0

[ Name ]:
Piperazine

[Synonym ]:
PIPERAZINE CHIPS
Hexahydropyrazine
Pyrazine hexahydride
Trimetazidine Hydrochloride Impurity G
1,4-diazacyclohexane
1,4-piperazine
Diethylenediamine
Piperazine
1,4-Diazacyclohexan
EINECS 203-808-3
MFCD00005953
1,4-DIAZACYCLOHEXANE, CERTIFIED REFERENCE MATERIAL
1,4-Diazacyclohexane,Diethylenediamine
Trimetazidine Impurity G

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
149.3±8.0 °C at 760 mmHg

[ Melting Point ]:
109-112 °C(lit.)

[ Molecular Formula ]:
C₄H₁₀N₂

[ Molecular Weight ]:
86.136

[ Flash Point ]:
49.7±10.2 °C

[ Exact Mass ]:
86.084396

[ PSA ]:
24.06000

[ LogP ]:
-1.17

[ Vapour Pressure ]:
4.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.424

[ Stability ]:
Stable. Hygroscopic. Light sensitive. Flammable. Incompatible with strong oxidizing agents.

[ Water Solubility ]:
150 g/L (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TK7800000

CHEMICAL NAME :: Piperazine

CAS REGISTRY NUMBER :: 110-85-0

BEILSTEIN REFERENCE NO. :: 0102555

LAST UPDATED :: 199704

DATA ITEMS CITED :: 19

MOLECULAR FORMULA :: C4-H10-N2

MOLECULAR WEIGHT :: 86.16

WISWESSER LINE NOTATION :: T6M DMTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 7/16/1967

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 29,1363,1946

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,862,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Behavioral - sleep Gastrointestinal - nausea or vomiting

REFERENCE :: 34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969 Volume(issue)/page/year: -,478,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1900 mg/kg

TOXIC EFFECTS :: Behavioral - excitement Behavioral - changes in motor activity (specific assay) Behavioral - muscle contraction or spasticity

REFERENCE :: TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 15,116,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,635,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1340 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,635,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,635,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 103,414,1964

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5400 mg/m3/2H

TOXIC EFFECTS :: Behavioral - excitement Behavioral - changes in motor activity (specific assay) Behavioral - muscle contraction or spasticity

REFERENCE :: TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 15,116,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PBPHAW Progress in Biochemical Pharmacology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1965- Volume(issue)/page/year: 1,542,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,635,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 4 mL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 7/16/1965 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-FINLAND:TWA 1 mg/m3;STEL 5 mg/m3;Skin JAN 1993 OEL-SWEDEN:TWA 0.1 ppm (0.3 mg/m3);STEL 0.3 ppm (1 mg/m3) JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84705 No. of Facilities: 132 (estimated) No. of Industries: 4 No. of Occupations: 11 No. of Employees: 2512 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84705 No. of Facilities: 435 (estimated) No. of Industries: 10 No. of Occupations: 25 No. of Employees: 8786 (estimated) No. of Female Employees: 2609 (estimated)

Safety Information

[ Symbol ]:

GHS05, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314-H317-H334-H361fd

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
C:Corrosive

[ Risk Phrases ]:
R34;R42/43;R52/53

[ Safety Phrases ]:
S22-S26-S36/37/39-S45-S61

[ RIDADR ]:
UN 2579 8/PG 3

[ WGK Germany ]:
1

[ RTECS ]:
TK7800000

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
2933599090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2406 i.s.
Ethylene glycol
ETHYLENE OXIDE
dea
2-Aminoethanol
1,4-Dioxane-2,5-diol
Piperazine,1,4-bis[(4-methylphenyl)sulfonyl]-
dichloroethane
1,2-Ethanediamine
1,3-Diaminopropane

DownStream

1-Piperazineethanol, a-methyl-
alpha,alpha-Dimethylpiperazine-1,4-diethanol
1-(2,4-difluorophenyl)-6,8-difluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid
1-diethoxyphosphorylpiperazine
Phenol, 4-nitro-, ion(1-) (9CI)
4,6-Dimethoxy-2-(piperazin-1-yl)pyrimidine
2-(1-Piperazinyl)-3-pyridinecarboxylic acid methyl ester
1-(2,4-difluorophenyl)-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid
7-piperazin-1-ylthieno[2,3-c]pyridine
5-piperazin-1-ylisoquinoline

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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