Meclizine dihydrochloride
Suppliers
Names
[ CAS No. ]:
1104-22-9
[ Name ]:
Meclizine dihydrochloride
[Synonym ]:
Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-, hydrochloride (1:2)
Piperazine, 1- (p-chloro-α-phenylbenzyl)-4-(m-methylbenzyl)-, dihydrochloride
EINECS 214-164-8
Meclizine diHCl
UNII:L997QXC9J1
ancolandihydrochloride
Meclizine (dihydrochloride)
1-((4-Chlorophenyl)(phenyl)methyl)-4-(3-methylbenzyl)piperazine dihydrochloride
Meclozine Hcl
UNII:408UZ554UD
diadril
Meclozine dihydrochloride
UNII:V5604WJ3XP
mecilizine hydrochloride
bonamine
MFCD00058199
1-[(4-Chlorophenyl)(phenyl)methyl]-4-(3-methylbenzyl)piperazine dihydrochloride
Navidoxine
Meclizine 2HCl
Chemical & Physical Properties
[ Density]:
1.159g/cm3
[ Boiling Point ]:
495.3ºC at 760mmHg
[ Melting Point ]:
212 °C
[ Molecular Formula ]:
C25H29Cl3N2
[ Molecular Weight ]:
463.870
[ Flash Point ]:
253.3ºC
[ Exact Mass ]:
462.139618
[ PSA ]:
6.48000
[ LogP ]:
7.03540
[ Vapour Pressure ]:
6E-10mmHg at 25°C
[ Storage condition ]:
2-8°C
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TL2005000
- CHEMICAL NAME :
- Piperazine, 1-(p-chloro-alpha-phenylbenzyl)-4-(m-methylbenzyl)-, dihydrochloride
- CAS REGISTRY NUMBER :
- 1104-22-9
- LAST UPDATED :
- 199803
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C25-H27-Cl-N2.2Cl-H
- MOLECULAR WEIGHT :
- 463.91
- WISWESSER LINE NOTATION :
- T6N DNTJ AYR&R DG& D1R C1 &GH 2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1600 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,67,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 625 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Lungs, Thorax, or Respiration - respiratory obstruction
- REFERENCE :
- JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 43,653,1954 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 800 mg/kg
- SEX/DURATION :
- female 8-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - homeostasis Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
- REFERENCE :
- MPHEAE Medicina et Pharmacologia Experimentalis. (Basel, Switzerland) V.12-17, 1965-67. For publisher information, see PHMGBN. Volume(issue)/page/year: 15,375,1966
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 800 mg/kg
- SEX/DURATION :
- female 8-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- REFERENCE :
- MPHEAE Medicina et Pharmacologia Experimentalis. (Basel, Switzerland) V.12-17, 1965-67. For publisher information, see PHMGBN. Volume(issue)/page/year: 15,375,1966
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 1 gm/kg
- SEX/DURATION :
- female 8-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
- REFERENCE :
- MPHEAE Medicina et Pharmacologia Experimentalis. (Basel, Switzerland) V.12-17, 1965-67. For publisher information, see PHMGBN. Volume(issue)/page/year: 15,375,1966
Safety Information
[ Symbol ]:
GHS07, GHS08
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302-H361
[ Precautionary Statements ]:
P280-P301 + P312 + P330
[ Hazard Codes ]:
Xn: Harmful;
[ Risk Phrases ]:
R22
[ Safety Phrases ]:
S22-S36
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
TL2005000
[ HS Code ]:
2933499090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933499090
[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%