Paroxetine hydrochloride hydrate

Suppliers

Names

[ Name ]:
Paroxetine hydrochloride hydrate

[Synonym ]:
paroxetine hydrochloride ;(-)trans-3-[(1,3-benzodioxol-5-yloxy) methyl]-4-(4-fluorophenyl) paroxetine hydrochloride
(3S,4R)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine hydrochloride hydrate (2:2:1)
Piperidine, 3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-, (3S,4R)-, hydrochloride, hydrate (2:2:1)
Paroxetine Hydrochloride HeMihydrate
Paroxetine hydrochl
Paroxetine hydrochloride
Paroxetine hydrochloride hydrate
Paroxetine (hydrochloride hemihydrate)

Chemical & Physical Properties

[ Density]:
1.213g/cm3

[ Boiling Point ]:
451.7ºC at 760mmHg

[ Melting Point ]:
121-131ºC

[ Molecular Formula ]:
C₁₉H₂₂ClFNO_3.5

[ Molecular Weight ]:
374.83

[ Flash Point ]:
227ºC

[ PSA ]:
39.72000

[ LogP ]:
4.45730

[ Appearance of Characters ]:
white

[ Water Solubility ]:
Slightly soluble in water, freely soluble in methanol, sparingly soluble in ethanol (96 per cent) and in methylene chloride.

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P301 + P312 + P330-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
F,C

[ Risk Phrases ]:
11-34-36/37/38-22

[ Safety Phrases ]:
16-26-36/37/39-45-36

[ RIDADR ]:
3077.0

[ RTECS ]:
TM4569320

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

phenyl (3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine-1-carboxylate
(3S,4R)-trans-1-benzyloxycarbonyl-4-(4-fluorophenyl)-3-[(3,4-methylenedioxyphenyl)oxymethyl]piperidine
Sesamol
Paroxetine
4-Fluorobenzaldehyde
(3S)-3-Z-AMINO-1-DIAZO-2-BUTANONE
((3S,4R)-4-(4-Fluorophenyl)piperidin-3-yl)methanol
methyl (3S,4R)-4-(4-fluorophenyl)piperidine-3-carboxylate

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

A new SiF-Dipropargyl glycerol scaffold as a versatile prosthetic group to design dimeric radioligands: synthesis of the [(18) F]BMPPSiF tracer to image serotonin receptors.

ChemMedChem 9(2) , 337-49, (2014)

A novel SiX-dipropargyl glycerol scaffold (X: H, F, or (18) F) was developed as a versatile prosthetic group that provides technical advantages for the preparation of dimeric radioligands based on sil...

A thorough QTc study of 3 doses of iloperidone including metabolic inhibition via CYP2D6 and/or CYP3A4 and a comparison to quetiapine and ziprasidone.

J. Clin. Psychopharmacol. 33(1) , 3-10, (2013)

The potential for iloperidone, a D2/5-HT2A antipsychotic, to affect the heart rate-corrected QT interval (QTc) was assessed in the absence and presence of metabolic inhibitors in a randomized, open-la...

A screen of approved drugs and molecular probes identifies therapeutics with anti-Ebola virus activity.

Sci. Transl. Med. 7 , 290ra89, (2015)

Currently, no approved therapeutics exist to treat or prevent infections induced by Ebola viruses, and recent events have demonstrated an urgent need for rapid discovery of new treatments. Repurposing...

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