(E)-Dosulepin
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Names
[ CAS No. ]:
113-53-1
[ Name ]:
(E)-Dosulepin
[Synonym ]:
1-Propanamine, 3-dibenzo[b,e]thiepin-11(6H)-ylidene-N,N-dimethyl-, (3E)-
11-(3-Dimethylamino-propyliden)-6,11-dihydro-dibenzo<b.e>thiepin
Methiaden
Dothiepin
Dolsulepine
Dosulepin
Prothiadene
Dosulepine
11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenzo(b,e)thiepin
(3E)-3-(Dibenzo[b,e]thiepin-11(6H)-ylidene)-N,N-dimethyl-1-propanamine
досулепин
iz914
Dothep
trans-dothiepin
Prothiaden
11(16H)-(3-[dimethylamino]propylidene)dibenz[b,e]thiopine
EINECS 204-031-2
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
430.9±44.0 °C at 760 mmHg
[ Melting Point ]:
55-57ºC
[ Molecular Formula ]:
C19H21NS
[ Molecular Weight ]:
295.44
[ Flash Point ]:
214.4±28.4 °C
[ Exact Mass ]:
295.139465
[ PSA ]:
28.54000
[ LogP ]:
4.34
[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C
[ Index of Refraction ]:
1.661
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UI1555000
- CHEMICAL NAME :
- Propylamine, N,N-dimethyl-3-(dibenzo(b,e)thiepin-delta-sup(11(6H), gamma))-
- CAS REGISTRY NUMBER :
- 113-53-1
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C19-H21-N-S
- MOLECULAR WEIGHT :
- 295.47
- WISWESSER LINE NOTATION :
- T C676 BY IS JHJ BU3N1&1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - infant
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - coma Cardiac - arrhythmias (including changes in conduction)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 4500 ug/kg
- TOXIC EFFECTS :
- Behavioral - changes in motor activity (specific assay)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 3214 ug/kg/12D-I
- TOXIC EFFECTS :
- Behavioral - changes in psychophysiological tests
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 2143 ug/kg/8D-I
- TOXIC EFFECTS :
- Behavioral - sleep Behavioral - hallucinations, distorted perceptions Behavioral - changes in psychophysiological tests
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 31 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 150 mg/kg
- SEX/DURATION :
- male 6 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)
- TYPE OF TEST :
- Cytogenetic analysis
MUTATION DATA
- TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 150 mg/kg
- REFERENCE :
- ACNSAX Activitas Nervosa Superior. (Avicenum, Malostranske nam. 28, Prague 1, Czechoslovakia) V.1- 1959- Volume(issue)/page/year: 15,114,1973
Safety Information
[ RIDADR ]:
UN 3249
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1(b)