Apaziquone

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Names

[ CAS No. ]:
114560-48-4

[ Name ]:
Apaziquone

[Synonym ]:
Neoquin
NOR-701
1H-Indole-4,7-dione, 5-(1-aziridinyl)-3-(hydroxymethyl)-2-(3-hydroxy-1-propen-1-yl)-1-methyl-
EO-9
5-(1-Aziridinyl)-3-(hydroxymethyl)-2-(3-hydroxy-1-propen-1-yl)-1-methyl-1H-indole-4,7-dione
Apaziquonum
Apaziquone
EOquin

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
632.3±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C15H16N2O4

[ Molecular Weight ]:
288.298

[ Flash Point ]:
336.2±31.5 °C

[ Exact Mass ]:
288.110992

[ PSA ]:
82.54000

[ LogP ]:
-1.36

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.682

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NL7873970
CHEMICAL NAME :
1H-Indole-4,7-dione, 5-(1-aziridinyl)-3-(hydroxymethyl)-2-(3-hydroxy-1-pro penyl)-1-methyl-, (E)-
CAS REGISTRY NUMBER :
114560-48-4
LAST UPDATED :
199709
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C15-H16-N2-O4
MOLECULAR WEIGHT :
288.33

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>450 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJCTEA European Journal of Cancer Part A. (Pergamon Press, c/o Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591) V.28A(4/5)- 1992- Volume(issue)/page/year: 29A,897,1993
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
13 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJCTEA European Journal of Cancer Part A. (Pergamon Press, c/o Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591) V.28A(4/5)- 1992- Volume(issue)/page/year: 29A,897,1993

Synthetic Route

Click to get detail synthetic route

Related Compounds

  • APAZIQUONE
  • Carbamic acid, N-[(3S,4R)-4-(2-bromophenyl)-3-pyrrolidinyl]-, 1,1-dimethylethyl ester
  • tert-butyl N-[(3S,4R)-4-(2-fluorophenyl)pyrrolidin-3-yl]carbamate
  • tert-Butyl ((3R,4S)-4-(3-chlorophenyl)pyrrolidin-3-yl)carbamate
  • tert-butyl N-[1-(2-chloropyridin-4-yl)ethyl]carbamate
  • 2-Tert-butyloxycarbonylaminomethyl-5-(4-tert-butylphenyl)-[1,3,4]oxadiazole
  • 2-Tert-butyloxycarbonylaminomethyl-5-phenyl-[1,3,4]oxadiazole
  • 2-Tert-butyloxycarbonylaminomethyl-5-thiophen-2-YL-[1,3,4]oxadiazole
  • (9H-fluoren-9-yl)methyl N-[2-hydroxy-2-(4-methylphenyl)ethyl]carbamate
  • (9H-fluoren-9-yl)methyl N-[2-(4-fluorophenyl)-2-hydroxyethyl]carbamate
  • (9H-fluoren-9-yl)methyl N-(2-hydroxy-2-phenylethyl)carbamate
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