Apaziquone

Modify Date: 2024-01-07 17:45:34

Apaziquone structure	Common Name	Apaziquone
	CAS Number	114560-48-4	Molecular Weight	288.298
	Density	1.5±0.1 g/cm3	Boiling Point	632.3±55.0 °C at 760 mmHg
	Molecular Formula	C₁₅H₁₆N₂O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	336.2±31.5 °C

Use of Apaziquone

Apaziquone (EO-9), an analog of Mitomycin C, is a prodrug that is activated to DNA damaging species by oxidoreductases (particularly NQO1). Apaziquone has the ability to kill aerobic and/or hypoxic cancer cells. Apaziquone, a bioreductive alkylating agent, inhibits cell proliferation and induces apoptosis in oral squamous cell carcinoma (OSCC) cells. Apaziquone significantly reduces oral tumor xenograft volume in immunocompromised NOD/SCID/Crl mice[1][2].

Name	5-(aziridin-1-yl)-3-(hydroxymethyl)-2-[(E)-3-hydroxyprop-1-enyl]-1-methylindole-4,7-dione
Synonym	More Synonyms

Description	Apaziquone (EO-9), an analog of Mitomycin C, is a prodrug that is activated to DNA damaging species by oxidoreductases (particularly NQO1). Apaziquone has the ability to kill aerobic and/or hypoxic cancer cells. Apaziquone, a bioreductive alkylating agent, inhibits cell proliferation and induces apoptosis in oral squamous cell carcinoma (OSCC) cells. Apaziquone significantly reduces oral tumor xenograft volume in immunocompromised NOD/SCID/Crl mice[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
References	[1]. Gunjan Srivastava, et al. Anticancer Activity of Apaziquone in Oral Cancer Cells and Xenograft Model: Implications for Oral Cancer Therapy. PLoS One. 2015 Jul 24;10(7):e0133735.

Density	1.5±0.1 g/cm3
Boiling Point	632.3±55.0 °C at 760 mmHg
Molecular Formula	C₁₅H₁₆N₂O₄
Molecular Weight	288.298
Flash Point	336.2±31.5 °C
Exact Mass	288.110992
PSA	82.54000
LogP	-1.36
Vapour Pressure	0.0±2.0 mmHg at 25°C
Index of Refraction	1.682

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NL7873970

CHEMICAL NAME :: 1H-Indole-4,7-dione, 5-(1-aziridinyl)-3-(hydroxymethyl)-2-(3-hydroxy-1-pro penyl)-1-methyl-, (E)-

CAS REGISTRY NUMBER :: 114560-48-4

LAST UPDATED :: 199709

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C15-H16-N2-O4

MOLECULAR WEIGHT :: 288.33

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >450 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJCTEA European Journal of Cancer Part A. (Pergamon Press, c/o Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591) V.28A(4/5)- 1992- Volume(issue)/page/year: 29A,897,1993

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 13 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJCTEA European Journal of Cancer Part A. (Pergamon Press, c/o Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591) V.28A(4/5)- 1992- Volume(issue)/page/year: 29A,897,1993

N/A

CAS#:169196-04-7

Apaziquone

CAS#:114560-48-4

Literature: Synthesis, , # 5 p. 633 - 636

Neoquin

NOR-701

1H-Indole-4,7-dione, 5-(1-aziridinyl)-3-(hydroxymethyl)-2-(3-hydroxy-1-propen-1-yl)-1-methyl-

EO-9

5-(1-Aziridinyl)-3-(hydroxymethyl)-2-(3-hydroxy-1-propen-1-yl)-1-methyl-1H-indole-4,7-dione

Apaziquonum

Apaziquone

EOquin

DC Chemicals Limited
China
Product Name: Apaziquone
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: APAZIQUONE,1H-INDOLE-4,7-DIONE, 5-(1-AZIRIDINYL)-3-(HYDROXYMETHYL)-2-(3-HYDROXY-1-PROPENYL)-1-METHYL-, (E)-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Apaziquone

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