Avagacestat

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Names

[ CAS No. ]:
1146699-66-2

[ Name ]:
Avagacestat

[Synonym ]:
(R)-2-(4-chloro-N-(2-fluoro-4-(1,2,4-oxadiazol-3-yl)benzyl)phenylsulfonamido)-5,5,5-trifluoropentanamide
BMS-708163
Avagacestat
Pentanamide, 2-[[(4-chlorophenyl)sulfonyl][[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoro-, (2R)-
N-[(4-Chlorophenyl)sulfonyl]-5,5,5-trifluoro-N-[2-fluoro-4-(1,2,4-oxadiazol-3-yl)benzyl]norvalinamide

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
652.3±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C20H17ClF4N4O4S

[ Molecular Weight ]:
520.885

[ Flash Point ]:
348.3±34.3 °C

[ Exact Mass ]:
520.059509

[ PSA ]:
127.77000

[ LogP ]:
4.89

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.564

[ Storage condition ]:
-20℃

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P305 + P351 + P338

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • (R)-2-(4-chloro-N-(2-fluoro-4-(N'-hydroxycarbamimidoyl)benzyl)phenylsulfonamido)-5,5,5-trifluoropentanamide
  • Triethyl orthoformate
  • 3-(4-(Bromomethyl)-3-fluorophenyl)-1,2,4-oxadiazole
  • Pentanamide, 2-[[(4-chlorophenyl)sulfonyl]amino]-5,5,5-trifluoro-, (2R)-

DownStream

Related Compounds

  • Ethyl 2-amino-7-methoxyquinoline-3-carboxylate
  • 4-Methanesulfonyl-3-methylbutanoic acid
  • {1-[({[3-(2-fluoro-4-methoxyphenyl)-6-oxopyridazin-1(6H)-yl]acetyl}amino)methyl]cyclohexyl}acetic acid
  • 4-[({[6-oxo-3-(thiophen-2-yl)pyridazin-1(6H)-yl]acetyl}amino)methyl]benzoic acid
  • 4-[({[3-(naphthalen-2-yl)-6-oxopyridazin-1(6H)-yl]acetyl}amino)methyl]benzoic acid
  • 6-(6-Chloro-5-((2-methoxyethoxy)methoxy)pyridin-3-yl)-4-morpholinoquinoline
  • 2-benzyl-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid
  • 4-[({[3-(3,4-dimethoxyphenyl)-6-oxopyridazin-1(6H)-yl]acetyl}amino)methyl]benzoic acid
  • 4-butyl-N-cyclopropyl-2-(1H-pyrrol-1-yl)-1,3-thiazole-5-carboxamide
  • N-[3-(6-Chloro-pyrimidin-4-ylamino)-benzyl]-methanesulfonamide
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