Z-Pro-OH

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Names

[ CAS No. ]:
1148-11-4

[ Name ]:
Z-Pro-OH

[Synonym ]:
(S)-N-(benzyloxycarbonyl)-proline
Cbz-L-proline
1,2-Pyrrolidinedicarboxylic acid, 1-benzyl ester, L-
EINECS 214-557-4
(S)-1-(benzyloxycarbonyl)-pyrrolidine-2-carboxylic acid
(S)-N-CBZ-pyrrolidine-2-carboxylic acid
N-Benzyloxycarbonyl-L-proline
N-Carbobenzyloxy-L-proline
(2S)-1-[(Phenylmethoxy)carbonyl]pyrrolidine-2-carboxylic acid
Carbobenzyloxy-L-proline
MFCD00003170
1,2-Pyrrolidinedicarboxylic acid, 1-(phenylmethyl) ester, (2S)-
N-Carbobenzoxy-L-proline
(S)-1-carbobenzoxypyrrolidine-2-carboxylic acid
MFCD00020830
1,2-Pyrrolidinedicarboxylic acid, 1-(phenylmethyl) ester, (S)-
Carbobenzoxy-L-proline
1-[(Benzyloxy)carbonyl]-L-proline
N-Cbz-L-proline
N-benzyloxycarbonyl-(S)-proline
(2S)-1-Phenylmethoxycarbonylpyrrolidine-2-carboxylicacid
Z-L-Proline
1,2-Pyrrolidinedicarboxylic acid, 1-(phenylmethyl) ester, (S)- (9CI)
Z-Pro-OH
N-[(phenyl-methoxy)carbonyl]-L-proline
Benzyloxycarbonyl-L-proline

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
432.3±45.0 °C at 760 mmHg

[ Melting Point ]:
76-78ºC

[ Molecular Formula ]:
C13H15NO4

[ Molecular Weight ]:
249.262

[ Flash Point ]:
215.3±28.7 °C

[ Exact Mass ]:
249.100113

[ PSA ]:
66.84000

[ LogP ]:
1.17

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.582

[ Storage condition ]:
2~8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UY0745000
CHEMICAL NAME :
1,2-Pyrrolidinedicarboxylic acid, 1-benzyl ester, L-
CAS REGISTRY NUMBER :
1148-11-4
LAST UPDATED :
199406
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C13-H15-N-O4
MOLECULAR WEIGHT :
249.29

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravaginal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 68,696,1979 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
280 mg/kg
SEX/DURATION :
female 28 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 68,696,1979
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravaginal
DOSE :
280 ug/kg
SEX/DURATION :
female 28 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 68,696,1979

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R62

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
UY0745000

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Benzyl chloroformate
  • Proline
  • Phenyl chloroformate
  • Cbz-L-Prolinol
  • N-(2-nitrophenylsulphonyl)pyrrolidine-2-carboxylic acid
  • (S)-1-Benzyl 2-methyl pyrrolidine-1,2-dicarboxylate
  • N-Benzyloxycarbonyl-N-trifluoromethylsulfonyl-4-trifluoromethylanilide
  • 1-BENZYL 2-METHYL PYRROLIDINE-1,2-DICARBOXYLATE

DownStream

  • benzyl (2S)-2-[5-(4-bromophenyl)-1H-imidazol-2-yl]pyrrolidine-1-c arboxylate
  • tert-butyl N-[(5S)-5-amino-6-[(2S)-2-[[(2S)-1-[[(2S)-1-[2-chloroethyl(nitroso)carbamoyl]pyrrolidine-2-carbonyl]amino]-3-methyl-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-6-oxohexyl]carbamate
  • (2S)-2-N-[(2S)-2-[[(2S)-1-[(2S)-2-amino-6-formamidohexanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]-1-N-(2-chloroethyl)-1-N-nitrosopyrrolidine-1,2-dicarboxamide
  • Benzyl 2-Formylpyrrolidine-1-carboxylate
  • Z-Pro-ONp
  • Z-Pro-NH2
  • Z-Pro-Leu-Gly-NH2
  • 1-[(2S)-2-Pyrrolidinylmethyl]pyrrolidine
  • (S)-BENZYL 2-(PYRROLIDINE-1-CARBONYL)PYRROLIDINE-1-CARBOXYLATE
  • benzyl (2S)-2-(2-bromoacetyl)pyrrolidine-1-carboxylate

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Prolidase is required for early trafficking events during influenza A virus entry.

J. Virol. 88(19) , 11271-83, (2014)

Influenza A virus (IAV) entry is a multistep process that requires the interaction of the virus with numerous host factors. In this study, we demonstrate that prolidase (PEPD) is a cellular factor req...

N-benzyloxycarbonyl-L-proline: an in vitro and in vivo inhibitor of prolidase.

Biochim. Biophys. Acta 1744(2) , 157-63, (2005)

Prolidase deficiency (PD) is a recessive disorder of the connective tissue caused by mutations in the prolidase, a specific peptidase, cleaving the dipeptides with a C-terminal prolyl and hydroxyproly...

Proline prodrug of melphalan targeted to prolidase, a prodrug activating enzyme overexpressed in melanoma.

Pharm. Res. 24(7) , 1290-8, (2007)

To determine the bioactivation and uptake of prolidase-targeted proline prodrugs of melphalan in six cancer cell lines with variable prolidase expression and to evaluate prolidase-dependence of prodru...


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Related Compounds

  • Z-Pro-OH
  • PZ-PRO-OH
  • Z-Pro-Pro-OH
  • Z-Pro-Phe-OH
  • Z-Pro-Met-OH
  • Z-Pro-Arg-OH
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  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-((1-methyl-5-(thiophen-2-yl)-1H-pyrazol-3-yl)methyl)-4-(morpholinosulfonyl)benzamide
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide