Z-Pro-OH
Modify Date: 2025-08-21 13:35:07
Z-Pro-OH structure
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Common Name | Z-Pro-OH | ||
|---|---|---|---|---|
| CAS Number | 1148-11-4 | Molecular Weight | 249.262 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 432.3±45.0 °C at 760 mmHg | |
| Molecular Formula | C13H15NO4 | Melting Point | 76-78ºC | |
| MSDS | Chinese USA | Flash Point | 215.3±28.7 °C | |
Use of Z-Pro-OHCarbobenzoxyproline (L-Cbz-Proline) is an inhibitor of prolidase. Carbobenzoxyproline can be used for prolidase deficiency (PD) research[1]. |
| Name | (2S)-1-phenylmethoxycarbonylpyrrolidine-2-carboxylic acid |
|---|---|
| Synonym | More Synonyms |
| Description | Carbobenzoxyproline (L-Cbz-Proline) is an inhibitor of prolidase. Carbobenzoxyproline can be used for prolidase deficiency (PD) research[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Carbobenzoxyproline (6 mM; 0-10 d; pH=6.0) causes mitochondrial depolarization and increases cellular death by 33% as reported for long-term culture of fibroblasts from prolidase deficiency (PD) patients[1]. Carbobenzoxyproline (0, 1, 3, 6 mM; 1 min; pH=6.0) results fibroblasts prolidase (FBP) hydrolysis, shows linear competitive inhibition[1]. |
| In Vivo | Carbobenzoxyproline (60 mg/kg; injection; once daily; 3 weeks) serves as in vivo inhibitor of erythrocytes prolidase in mice model[1]. Animal Model: C57Bl/6J mice (4-week-old)[1] Dosage: 60 mg/kg Administration: Injection; once daily for 3 weeks Result: Resulted significant reduction of erythrocytes prolidase activity. |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 432.3±45.0 °C at 760 mmHg |
| Melting Point | 76-78ºC |
| Molecular Formula | C13H15NO4 |
| Molecular Weight | 249.262 |
| Flash Point | 215.3±28.7 °C |
| Exact Mass | 249.100113 |
| PSA | 66.84000 |
| LogP | 1.17 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.582 |
| Storage condition | 2~8°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| Precursor 8 | |
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| DownStream 10 | |
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CAS#:108645-62-1![benzyl (2S)-2-[5-(4-bromophenyl)-1H-imidazol-2-yl]pyrrolidine-1-c arboxylate structure](https://image.chemsrc.com/caspic/414/1007882-39-4.png)
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CAS#:106039-80-9![(2S)-2-N-[(2S)-2-[[(2S)-1-[(2S)-2-amino-6-formamidohexanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]-1-N-(2-chloroethyl)-1-N-nitrosopyrrolidine-1,2-dicarboxamide structure](https://image.chemsrc.com/caspic/146/106039-85-4.png)
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CAS#:223785-66-8| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Prolidase is required for early trafficking events during influenza A virus entry.
J. Virol. 88(19) , 11271-83, (2014) Influenza A virus (IAV) entry is a multistep process that requires the interaction of the virus with numerous host factors. In this study, we demonstrate that prolidase (PEPD) is a cellular factor req... |
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N-benzyloxycarbonyl-L-proline: an in vitro and in vivo inhibitor of prolidase.
Biochim. Biophys. Acta 1744(2) , 157-63, (2005) Prolidase deficiency (PD) is a recessive disorder of the connective tissue caused by mutations in the prolidase, a specific peptidase, cleaving the dipeptides with a C-terminal prolyl and hydroxyproly... |
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Proline prodrug of melphalan targeted to prolidase, a prodrug activating enzyme overexpressed in melanoma.
Pharm. Res. 24(7) , 1290-8, (2007) To determine the bioactivation and uptake of prolidase-targeted proline prodrugs of melphalan in six cancer cell lines with variable prolidase expression and to evaluate prolidase-dependence of prodru... |
| (S)-N-(benzyloxycarbonyl)-proline |
| Cbz-L-proline |
| 1,2-Pyrrolidinedicarboxylic acid, 1-benzyl ester, L- |
| EINECS 214-557-4 |
| (S)-1-(benzyloxycarbonyl)-pyrrolidine-2-carboxylic acid |
| (S)-N-CBZ-pyrrolidine-2-carboxylic acid |
| N-Benzyloxycarbonyl-L-proline |
| N-Carbobenzyloxy-L-proline |
| (2S)-1-[(Phenylmethoxy)carbonyl]pyrrolidine-2-carboxylic acid |
| Carbobenzyloxy-L-proline |
| MFCD00003170 |
| 1,2-Pyrrolidinedicarboxylic acid, 1-(phenylmethyl) ester, (2S)- |
| N-Carbobenzoxy-L-proline |
| (S)-1-carbobenzoxypyrrolidine-2-carboxylic acid |
| MFCD00020830 |
| 1,2-Pyrrolidinedicarboxylic acid, 1-(phenylmethyl) ester, (S)- |
| Carbobenzoxy-L-proline |
| 1-[(Benzyloxy)carbonyl]-L-proline |
| N-Cbz-L-proline |
| N-benzyloxycarbonyl-(S)-proline |
| (2S)-1-Phenylmethoxycarbonylpyrrolidine-2-carboxylicacid |
| Z-L-Proline |
| 1,2-Pyrrolidinedicarboxylic acid, 1-(phenylmethyl) ester, (S)- (9CI) |
| Z-Pro-OH |
| N-[(phenyl-methoxy)carbonyl]-L-proline |
| Benzyloxycarbonyl-L-proline |
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- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Z-Pro-OH
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- GL Biochem (Shanghai) Ltd.
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- Shanghai Jizhi Biochemical Technology Co., Ltd
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- ShangHai DC Chemicals Co.,Ltd
- China
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- DC Chemicals Limited
- China
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- Nanjing Peptide Biotech Ltd
- China
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- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: N-Benzyloxycarbonyl-L-proline
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- Henan Tianfu Chemical Co., Ltd.
- China
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