7,10-di-Troc-Docetaxel

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Names

[ CAS No. ]:
114915-14-9

[ Name ]:
7,10-di-Troc-Docetaxel

[Synonym ]:
(5β,7β,10β,13α)-4-Acetoxy-13-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7,10-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
(2α,5β,7β,10β,13α)-4-Acetoxy-1,7,10-trihydroxy-13-{[(2R,3S)-2-hydroxy-3-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)-3-phenylpropanoyl]oxy}-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
4-acetoxy-2-phenyl-2H-1-chromene
Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6, 11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
Docetaxel
10-deacetyl-7,10-diTroc-baccatin III
(2α,5β,7β,10β,13α)-4-Acetoxy-13-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7,10-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
N-debenzoyl-N-Boc-10-deacetyl taxol
Docetaxel intermediate
(2α,5β,7β,10β,13α)-4-(acetyloxy)-13-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7,10-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
N-debenzoyl-N-tert-butoxycarbonyl-10-deacetyl taxol
Docetaxol
2H-1-Benzopyran-4-ol,2-phenyl-,acetate
4-acetoxy-2-phenyl-2H-chromene
Taxotere
7,10-di-Troc-Docetaxel

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
900.5±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C43H53NO14

[ Molecular Weight ]:
807.879

[ Flash Point ]:
498.4±34.3 °C

[ Exact Mass ]:
807.346619

[ PSA ]:
224.45000

[ LogP ]:
6.55

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.618

[ Storage condition ]:
2~8°C

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 13-[(2'R,4'S,5'R)-3'-t-butoxycarbonyl-2'-(1'''-naphthyl)-4'-phenyl-1,3-oxazolidine-5-carbonyl]-7,10-(di-2'',2'',2''-trichloroethoxy carbonyl)-10-deacetylbaccatin III
  • Di-tert-butyl dicarbonate
  • N-Des-t-boc-10-deacetyl-7,10-O-bis{[(2,2,2-trichloroethyl)oxy]carbonyl} Docetaxel
  • Cabazitaxel N-3
  • sodium tert-butoxycarbonyl chloroamide
  • Ethyl 3-Azido-2-hydroxy-propionate
  • Benzaldehyde

DownStream

  • Deacetyltaxol
  • N-Des-t-boc-10-deacetyl-7,10-O-bis{[(2,2,2-trichloroethyl)oxy]carbonyl} Docetaxel

Related Compounds

  • (2'R,3'S)-7,10-di-Troc-docetaxel
  • 7,10-di-troc-N'-Boc-2'-acetyldocetaxel
  • 2'-THP-7,10-TROC-docetaxel
  • 2'-TES-7,10-TROC-docetaxel
  • 7,10-di-O-(2-chloroacetyl)docetaxel
  • 7,10-di-O-1,3-benzodithiolan-2-yl-10-DAB
  • Benzyl 2-(pyridin-4-yl)piperidine-1-carboxylate
  • 2-(Pyridin-4-yl)piperidine-1-carbaldehyde
  • 1-(2-(Pyridin-4-yl)piperidin-1-yl)ethanone
  • Phenyl(2-(pyridin-4-yl)piperidin-1-yl)methanone
  • 2-(6-Methylpyridin-2-yl)pyrrolidine-1-carbaldehyde
  • 2-(1-Benzylpyrrolidin-2-yl)-6-methylpyridine
  • 1-(2-(6-Methylpyridin-2-yl)pyrrolidin-1-yl)ethanone
  • Benzyl 2-(6-methylpyridin-2-yl)pyrrolidine-1-carboxylate
  • tert-Butyl 2-(6-methylpyridin-2-yl)pyrrolidine-1-carboxylate
  • (2-(6-Methylpyridin-2-yl)pyrrolidin-1-yl)(phenyl)methanone
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