2-Amino-2-methyl-1,3-propanediol
Suppliers
Names
[ CAS No. ]:
115-69-5
[ Name ]:
2-Amino-2-methyl-1,3-propanediol
[Synonym ]:
AMPD,Ammediol
1,3-Propanediol, 2-amino-2-methyl-
2-amino-2-methylpropane-1,3-diol
2-Amino-2-methyl-1,3-propanediol
EINECS 204-100-7
MFCD00004678
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
271.5±0.0 °C at 760 mmHg
[ Melting Point ]:
100-110 °C(lit.)
[ Molecular Formula ]:
C4H11NO2
[ Molecular Weight ]:
105.136
[ Flash Point ]:
109.7±21.8 °C
[ Exact Mass ]:
105.078979
[ PSA ]:
66.48000
[ LogP ]:
-1.16
[ Vapour density ]:
3.63 (vs air)
[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C
[ Index of Refraction ]:
1.494
[ Stability ]:
Stable. Combustible. May be moisture-sensitive. Incompatible with strong oxidizing agents, copper, aluminium, brass, strong acids.
[ Water Solubility ]:
2500 g/L (20 ºC)
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TY2975000
- CHEMICAL NAME :
- 1,3-Propanediol, 2-amino-2-methyl-
- CAS REGISTRY NUMBER :
- 115-69-5
- BEILSTEIN REFERENCE NO. :
- 0635708
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C4-H11-N-O2
- MOLECULAR WEIGHT :
- 105.16
- WISWESSER LINE NOTATION :
- Q1XZ1&1Q
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 17 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 9(2),203,1990
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 140 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 14,111,1985
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 1500 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Behavioral - coma
- REFERENCE :
- JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 22,315,1940 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82132 No. of Facilities: 38 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 66 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82132 No. of Facilities: 663 (estimated) No. of Industries: 2 No. of Occupations: 7 No. of Employees: 7513 (estimated) No. of Female Employees: 5523 (estimated)
Safety Information
[ Symbol ]:
GHS05, GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H290-H315-H319-H335
[ Precautionary Statements ]:
P280-P304 + P340 + P312-P305 + P351 + P338-P337 + P313
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi:Irritant;
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S26-S36-S37/39
[ RIDADR ]:
UN 3259 8/PG 2
[ WGK Germany ]:
1
[ RTECS ]:
TY2975000
[ Hazard Class ]:
8.0
[ HS Code ]:
29221980
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 29221980
Articles
Vet. Immunol. Immunopathol. 161(1-2) , 21-31, (2014)
Veterinary adult stem cell therapy is an emerging area of basic and clinical research. Like their human counterparts, veterinary mesenchymal stem cells (MSCs) offer many potential therapeutic benefits...
Mol. Med. Report. 12 , 877-84, (2015)
The differentiation of pluripotent mesenchymal stem cells to mature osteoblasts is crucial for the maintenance of the adult skeleton. In rheumatic arthritis, osteoblast differentiation is impaired by ...
Int. J. Toxicol. 28(6 Suppl) , 141S-61S, (2009)
Aminomethyl propanol and aminomethyl propanediol are substituted aliphatic alcohols that function as pH adjusters in cosmetic products at concentrations less than 10%; additionally, aminomethyl propan...