Tezacaftor(VX-661)

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Names

[ Name ]:
Tezacaftor(VX-661)

[Synonym ]:
Cyclopropanecarboxamide, 1-(2,2-difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(2-hydroxy-1,1-dimethylethyl)-1H-indol-5-yl]-
tezacaftorum
vx661
(r)-1-(2,2-difluorobenzo[d] [1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide
cs-1078
1-(2,2-Difluoro-1,3-benzodioxol-5-yl)-N-{1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(1-hydroxy-2-methyl-2-propanyl)-1H-indol-5-yl}cyclopropanecarboxamide
Tezacaftor

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
610.8±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₆H₂₇F₃N₂O₆

[ Molecular Weight ]:
520.498

[ Flash Point ]:
323.2±31.5 °C

[ Exact Mass ]:
520.182129

[ PSA ]:
113.18000

[ LogP ]:
2.65

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.628

[ Storage condition ]:
-20℃

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

(R)-N-(1-(3-(benzyloxy)-2-hydroxypropyl)-2-(1-(benzyloxy)-2-methylpropan-2-yl)-6-fluoro-1H-indol-5-yl)-1-(2,2-difluorohenzo[d][1,3] dioxol-5-yl)cyclopropanecarboxamide
3-Fluoro-4-nitroaniline
5-Bromo-2,2-difluorobenzodioxole
2,2-Difluorobenzodioxole-5-carboxylic acid
(2,2-Difluoro-1,3-benzodioxol-5-yl)methanol
5-(Chloromethyl)-2,2-difluorobenzo[d][1,3]dioxole
1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarbonitrile
2-Bromo-5-Fluoro-4-Nitroaniline
4-benzyloxy-3,3-dimethylbut-1-yne