Tezacaftor(VX-661)
Modify Date: 2024-01-02 21:36:20
Tezacaftor(VX-661) structure
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Common Name | Tezacaftor(VX-661) | ||
|---|---|---|---|---|
| CAS Number | 1152311-62-0 | Molecular Weight | 520.498 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 610.8±55.0 °C at 760 mmHg | |
| Molecular Formula | C26H27F3N2O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 323.2±31.5 °C | |
Use of Tezacaftor(VX-661)VX-661 is a second F508del CFTR corrector and help CFTR protein reach the cell surface. |
| Name | 1-(2,2-difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)indol-5-yl]cyclopropane-1-carboxamide |
|---|---|
| Synonym | More Synonyms |
| Description | VX-661 is a second F508del CFTR corrector and help CFTR protein reach the cell surface. |
|---|---|
| Related Catalog | |
| In Vitro | In vitro, a combination of VX-661 and ivacaftor results in greater CFTR activity compared with VX-661 alone[2]. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 610.8±55.0 °C at 760 mmHg |
| Molecular Formula | C26H27F3N2O6 |
| Molecular Weight | 520.498 |
| Flash Point | 323.2±31.5 °C |
| Exact Mass | 520.182129 |
| PSA | 113.18000 |
| LogP | 2.65 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.628 |
| Storage condition | -20℃ |
| Precursor 9 | |
|---|---|
| DownStream 0 | |
![(R)-N-(1-(3-(benzyloxy)-2-hydroxypropyl)-2-(1-(benzyloxy)-2-methylpropan-2-yl)-6-fluoro-1H-indol-5-yl)-1-(2,2-difluorohenzo[d][1,3] dioxol-5-yl)cyclopropanecarboxamide Structure](https://image.chemsrc.com/caspic/194/1294504-68-9.png)
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CAS#:1092536-54-3| Cyclopropanecarboxamide, 1-(2,2-difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(2-hydroxy-1,1-dimethylethyl)-1H-indol-5-yl]- |
| tezacaftorum |
| vx661 |
| (r)-1-(2,2-difluorobenzo[d] [1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide |
| cs-1078 |
| 1-(2,2-Difluoro-1,3-benzodioxol-5-yl)-N-{1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(1-hydroxy-2-methyl-2-propanyl)-1H-indol-5-yl}cyclopropanecarboxamide |
| Tezacaftor |