Ramatroban

Suppliers

Names

[ Name ]:
Ramatroban

[Synonym ]:
MFCD00887606
9H-Carbazole-9-propanoic acid, 3-[[(4-fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-, (3R)-
3-[(3R)-3-{[(4-Fluorophenyl)sulfonyl]amino}-1,2,3,4-tetrahydro-9H-carbazol-9-yl]propanoic acid
BAY u 3405
(+)-(3R)-3-(p-Fluorobenzenesulfonamido)-1,2,3,4-tetrahydrocarbazole-9-propionic acid
Baynas
3-((3R)-3-(((4-Fluorophenyl)sulfonyl)amino)-1,2,3,4-tetrahydro-9H-carbazol-9-yl)propanoic Acid
BAY u-3405
Ramatroban
3-[(3R)-3-[(4-fluorophenyl)sulfonylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]propanoic acid

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
654.7±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₂₁FN₂O₄S

[ Molecular Weight ]:
416.466

[ Flash Point ]:
349.7±34.3 °C

[ Exact Mass ]:
416.120605

[ PSA ]:
96.78000

[ LogP ]:
4.09

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.664

[ Storage condition ]:
Desiccate at -20°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36/37/39-45

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

(R)-N-[9-(2-cyanoethyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]-4-fluorobenzenesulfonamide
1,2,4,9-Tetrahydro-carbazol-3-one
1,4-Dioxaspiro[4.5]decan-8-one
(+/-)-2,3,4,9-tetrahydro-1H-carbazol-3-ol
Phenylhydrazine
5-oxo-tetrahydrocarbazole ethylene ketal
(3R)-2,3,4,9-Tetrahydro-1H-carbazol-3-amine
(S)-(-)-2,3,4,9-tetrahydro-1H-carbazol-3-ol
(S)-2,3,4,9-tetrahydro-1H-carbazol-3-yl methanesulfonate

DownStream

Articles

Interactive effect of histamine and prostaglandin D2 on nasal allergic symptoms in rats.

Eur. J. Pharmacol. 554(2-3) , 229-34, (2007)

This study was undertaken to investigate the interactive effect of histamine and prostaglandin D(2) in nasal allergic symptoms in rats. The intranasal application of histamine at doses lower than 10 m...

IL-16 variability and modulation by antiallergic drugs in a murine experimental allergic rhinitis model.

Int. Arch. Allergy Immunol. 149(4) , 315-22, (2009)

Interleukin-16 (IL-16) is a cytokine that induces selective migration of CD4+ cells and participates in inflammatory diseases including allergic rhinitis. Histamine and prostaglandin D(2) are importan...

Successful treatment of eosinophilic otitis media using ramatroban: report of two cases.

Auris. Nasus. Larynx. 33(4) , 455-60, (2006)

The pathogenesis of eosinophilic otitis media is not yet fully understood. The purpose of this paper is to describe the clinical course of our two patients with eosinophilic otitis media and to discus...