Combretastatin A4

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Names

[ CAS No. ]:
117048-59-6

[ Name ]:
Combretastatin A4

[Synonym ]:
(Z)-2-Methoxy-5-[2-(3,4,5,-trimethoxyphenyl)ethenyl]phenol
(Z)-CombretastatinA4
Phenol, 2-methoxy-5-(2-(3,4,5-trimethoxyphenyl)ethenyl)-, (Z)-
(Z)-2-Methoxy-5-(3,4,5-trimethoxystyryl)phenol
3'-Hydroxy-3,4,4',5-tetramethoxy-cis-stilbene
CS A4
2-Methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]benzolol
2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol
2-Methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)vinyl]phenol
Combretastatin A-4
3,4,5-Trimethoxy-3'-hydroxy-4'-methoxy-(Z)-stilbene
Phenol, 2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
490.3±45.0 °C at 760 mmHg

[ Melting Point ]:
84.5-85.5ºC

[ Molecular Formula ]:
C18H20O5

[ Molecular Weight ]:
316.348

[ Flash Point ]:
250.3±28.7 °C

[ Exact Mass ]:
316.131073

[ PSA ]:
57.15000

[ LogP ]:
3.57

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.607

[ Storage condition ]:
Desiccate at -20°C

[ Water Solubility ]:
DMSO: >10mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301 + H311 + H331-H318

[ Precautionary Statements ]:
P261-P280-P301 + P310-P305 + P351 + P338-P311

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T: Toxic;

[ Risk Phrases ]:
R23/24/25;R41

[ Safety Phrases ]:
26-36/37-39-45

[ RIDADR ]:
UN 2811

[ Packaging Group ]:
Ⅲ

[ Hazard Class ]:
6.0

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 3-tert-butyldimethylsilyloxy-3',4,4',5'-tetramethyloxystilbene
  • Isovanillin
  • Triphenyl-[(3,4,5-trimethoxyphenyl)-methyl]-phosphonium chloride
  • (E)-3-(3-acetoxy-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)acrylic acid
  • 3,4,5-Trimethoxybenzaldehyde
  • 3-hydroxy-4-methoxybenzyltriphenylphosphonium bromide
  • Triphenyl(3,4,5-trimethoxybenzyl)phosphonium bromide

DownStream

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Related Compounds

  • Combretastatin A4
  • Combretastatin A4 disodium phosphate
  • Combretastatin A4 disodium phosphate
  • combretastatin C-1
  • Combretastatin A-1
  • combretastatin B-3
  • 8-N-Ethylquinoline-5,8-diamine
  • methyl 3-(N-(5-isopentyl-3,3-dimethyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-8-yl)sulfamoyl)thiophene-2-carboxylate
  • 3-cyclopentyl-N-(3-((4-(m-tolyl)piperazin-1-yl)sulfonyl)propyl)propanamide
  • 6-(4-(2-fluorophenyl)piperazine-1-carbonyl)-7-(2-methoxyethyl)-1,3-dimethyl-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione
  • 2-[3-(2H-1,3-benzodioxol-5-yl)-2-oxoimidazolidin-1-yl]-N-[2-(4-fluorophenoxy)ethyl]acetamide
  • (E)-3-(furan-2-yl)-N-(4-methyl-5-oxo-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepin-7-yl)acrylamide
  • 2-methyl-N-(4-methyl-5-oxo-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepin-7-yl)thiazole-4-carboxamide
  • 5-(furan-2-yl)-N-(4-methyl-5-oxo-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepin-7-yl)isoxazole-3-carboxamide
  • (E)-3-(2-chlorophenyl)-N-(4-methyl-5-oxo-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepin-7-yl)acrylamide
  • 3-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-(4-methyl-5-oxo-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepin-7-yl)propanamide
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