Combretastatin A4
Combretastatin A4 structure
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Common Name | Combretastatin A4 | ||
|---|---|---|---|---|
| CAS Number | 117048-59-6 | Molecular Weight | 316.348 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 490.3±45.0 °C at 760 mmHg | |
| Molecular Formula | C18H20O5 | Melting Point | 84.5-85.5ºC | |
| MSDS | Chinese USA | Flash Point | 250.3±28.7 °C | |
| Symbol |
GHS05, GHS06 |
Signal Word | Danger | |
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Microfluidic Synthesis of Hybrid Nanoparticles with Controlled Lipid Layers: Understanding Flexibility-Regulated Cell-Nanoparticle Interaction.
ACS Nano 9 , 9912-21, (2015) The functionalized lipid shell of hybrid nanoparticles plays an important role for improving their biocompatibility and in vivo stability. Yet few efforts have been made to critically examine the shell structure of nanoparticles and its effect on cell-particl... |
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The vascular disrupting activity of OXi8006 in endothelial cells and its phosphate prodrug OXi8007 in breast tumor xenografts.
Cancer Lett. 369 , 229-41, (2015) This study describes the vascular disrupting ability and the mechanism of action of the indole-based tubulin-binding compound, OXi8006, and its water-soluble phosphate prodrug OXi8007. Treatment of rapidly proliferating human umbilical vein endothelial cells ... |
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PD806: a novel oral vascular disrupting agent shows antitumor and antivascular effects in vitro and in vivo.
Anticancer Drugs 26(2) , 148-59, (2014) The aim of this study was to investigate the antitumor and antivascular effects of PD806, a new oral prodrug of AVE8063 in vitro and in vivo. The cytotoxicity of PD806 was determined against H22, Walker 256, A549, MCF-7, and BEL-7402 cells using MTT assays. P... |
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Autophagy blockade sensitizes the anticancer activity of CA-4 via JNK-Bcl-2 pathway.
Toxicol. Appl. Pharmacol. 274(2) , 319-27, (2014) Combretastatin A-4 (CA-4) has already entered clinical trials of solid tumors over ten years. However, the limited anticancer activity and dose-dependent toxicity restrict its clinical application. Here, we offered convincing evidence that CA-4 induced autoph... |
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Cell Cycle Regulation of Smooth Muscle Cells--Searching for Inhibitors of Neointima Formation: Is Combretastatin A4 an Alternative to Sirolimus and Paclitaxel?
J. Vasc. Interv. Radiol. 26 , 1388-95, (2015) To compare the effects of sirolimus, paclitaxel, and combretastatin A4 (CA4) on regulatory proteins of the cell cycle in proliferating smooth muscle cells (SMCs).Human aortic SMCs were treated with sirolimus, paclitaxel, and CA4 at 5 × 10(-9) mol/L. After 1 d... |
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End-binding proteins sensitize microtubules to the action of microtubule-targeting agents.
Proc. Natl. Acad. Sci. U. S. A. 110(22) , 8900-5, (2013) Microtubule-targeting agents (MTAs) are widely used for treatment of cancer and other diseases, and a detailed understanding of the mechanism of their action is important for the development of improved microtubule-directed therapies. Although there is a larg... |
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Dynamic contrast enhanced fluorescent molecular imaging of vascular disruption induced by combretastatin-A4P in tumor xenografts.
J. Biomed. Nanotechnol. 10(8) , 1545-51, (2014) Dynamic contrast enhanced (DyCE) fluorescence imaging was recently demonstrated for identifying the organs in mice based on principal component analysis (PCA) of contrast kinetics following infusion of indocyanine green (ICG). It occurred to us that this appr... |
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Sequential systemic administrations of combretastatin A4 Phosphate and radioiodinated hypericin exert synergistic targeted theranostic effects with prolonged survival on SCID mice carrying bifocal tumor xenografts.
Theranostics 3(2) , 127-37, (2013) Based on the soil-to-seeds principle, we explored the small-molecular sequential dual-targeting theranostic strategy (SMSDTTS) for prolonged survival and imaging detectability in a xenograft tumor model.Thirty severe combined immunodeficiency (SCID) mice bear... |
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Synthesis of a 2-aryl-3-aroyl indole salt (OXi8007) resembling combretastatin A-4 with application as a vascular disrupting agent.
J. Nat. Prod. 76(9) , 1668-78, (2013) The natural products colchicine and combretastatin A-4 are potent inhibitors of tubulin assembly, and they have inspired the design and synthesis of a large number of small-molecule, potential anticancer agents. The indole-based molecular scaffold is prominen... |
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Distilling a Visual Network of Retinitis Pigmentosa Gene-Protein Interactions to Uncover New Disease Candidates.
PLoS ONE 10 , e0135307, (2015) Retinitis pigmentosa (RP) is a highly heterogeneous genetic visual disorder with more than 70 known causative genes, some of them shared with other non-syndromic retinal dystrophies (e.g. Leber congenital amaurosis, LCA). The identification of RP genes has in... |