hydroxychloroquine
Suppliers
Names
[ CAS No. ]:
118-42-3
[ Name ]:
hydroxychloroquine
[Synonym ]:
2-[4-[(7-chloroquinolin-4-yl)amino]pentyl-ethylamino]ethanol
EINECS 204-249-8
MFCD00078203
Oxichlorochinum
Plaquenil
Oxichloroquine
Polirreumin
Hydroxychlorochin
Oxychlorochin
Hidroxicloroquina
Quensyl
Oxychloroquine
Chemical & Physical Properties
[ Density]:
1.176 g/cm3
[ Boiling Point ]:
516.7ºC at 760 mmHg
[ Melting Point ]:
89-91°
[ Molecular Formula ]:
C18H26ClN3O
[ Molecular Weight ]:
335.87200
[ Flash Point ]:
266.3ºC
[ Exact Mass ]:
335.17600
[ PSA ]:
48.39000
[ LogP ]:
3.85600
[ Vapour Pressure ]:
1.68E-11mmHg at 25°C
[ Index of Refraction ]:
1.5790 (estimate)
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- KK3325000
- CHEMICAL NAME :
- Ethanol, 2-((4-((7-chloro-4-quinolyl)amino)pentyl)ethylamino)-
- CAS REGISTRY NUMBER :
- 118-42-3
- BEILSTEIN REFERENCE NO. :
- 0253894
- LAST UPDATED :
- 199703
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C18-H26-Cl-N3-O
- MOLECULAR WEIGHT :
- 335.92
- WISWESSER LINE NOTATION :
- T66 BNJ EMY1&3N2&2Q IG
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - child
- DOSE/DURATION :
- 600 mg/kg
- TOXIC EFFECTS :
- Brain and Coverings - increased intracranial pressure Behavioral - convulsions or effect on seizure threshold Cardiac - other changes
- REFERENCE :
- JATOD3 Journal of Analytical Toxicology. (Preston Pub. Inc., POB 48312, Niles, IL 60648) V.1- 1977- Volume(issue)/page/year: 14,186,1990
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 88 mg/kg/11D-I
- TOXIC EFFECTS :
- Skin and Appendages - dermatitis, allergic (after systemic exposure)
- REFERENCE :
- JAADDB Journal of the American Academy of Dermatology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) 1979- Volume(issue)/page/year: 12,857,1985
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 112 mg/kg/2W-I
- TOXIC EFFECTS :
- Skin and Appendages - dermatitis, irritative (after systemic exposure)
- REFERENCE :
- JRHUA9 Journal of Rheumatology. (920 Yonge St., Suite 608, Toronto, Ont., Canada) V.1- 1974- Volume(issue)/page/year: 12,391,1985
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 429 mg/kg/25D
- TOXIC EFFECTS :
- Blood - agranulocytosis Skin and Appendages - dermatitis, other (after systemic exposure)
- REFERENCE :
- LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 1,1275,1965
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 154 mg/kg/18D-I
- TOXIC EFFECTS :
- Behavioral - toxic psychosis
- REFERENCE :
- JAADDB Journal of the American Academy of Dermatology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) 1979- Volume(issue)/page/year: 12,863,1985
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1240 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 12,184,1969
Safety Information
[ Hazard Codes ]:
Xn
[ Risk Phrases ]:
R22;R36
[ Safety Phrases ]:
S26
[ HS Code ]:
3004390090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933499090
[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%