CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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KK3325000
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CHEMICAL NAME :
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Ethanol, 2-((4-((7-chloro-4-quinolyl)amino)pentyl)ethylamino)-
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CAS REGISTRY NUMBER :
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118-42-3
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BEILSTEIN REFERENCE NO. :
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0253894
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LAST UPDATED :
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199703
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DATA ITEMS CITED :
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6
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MOLECULAR FORMULA :
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C18-H26-Cl-N3-O
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MOLECULAR WEIGHT :
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335.92
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WISWESSER LINE NOTATION :
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T66 BNJ EMY1&3N2&2Q IG
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Human - child
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DOSE/DURATION :
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600 mg/kg
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TOXIC EFFECTS :
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Brain and Coverings - increased intracranial pressure Behavioral - convulsions or effect on seizure threshold Cardiac - other changes
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REFERENCE :
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JATOD3 Journal of Analytical Toxicology. (Preston Pub. Inc., POB 48312, Niles, IL 60648) V.1- 1977- Volume(issue)/page/year: 14,186,1990
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Human - woman
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DOSE/DURATION :
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88 mg/kg/11D-I
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TOXIC EFFECTS :
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Skin and Appendages - dermatitis, allergic (after systemic exposure)
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REFERENCE :
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JAADDB Journal of the American Academy of Dermatology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) 1979- Volume(issue)/page/year: 12,857,1985
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Human - woman
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DOSE/DURATION :
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112 mg/kg/2W-I
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TOXIC EFFECTS :
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Skin and Appendages - dermatitis, irritative (after systemic exposure)
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REFERENCE :
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JRHUA9 Journal of Rheumatology. (920 Yonge St., Suite 608, Toronto, Ont., Canada) V.1- 1974- Volume(issue)/page/year: 12,391,1985
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Human
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DOSE/DURATION :
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429 mg/kg/25D
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TOXIC EFFECTS :
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Blood - agranulocytosis Skin and Appendages - dermatitis, other (after systemic exposure)
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REFERENCE :
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LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 1,1275,1965
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Human - man
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DOSE/DURATION :
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154 mg/kg/18D-I
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TOXIC EFFECTS :
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Behavioral - toxic psychosis
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REFERENCE :
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JAADDB Journal of the American Academy of Dermatology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) 1979- Volume(issue)/page/year: 12,863,1985
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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1240 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 12,184,1969
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