Phenyl salicylate
Suppliers
Names
[ CAS No. ]:
118-55-8
[ Name ]:
Phenyl salicylate
[Synonym ]:
Phenyl-2-hydroxybenzoat
Salicylic acid phenyl ester
Seesorb 201
Benzoic acid, 2-hydroxy-, phenyl ester
Phenyl salicylate melting point
phenyl 2-hydroxybenzoate
Salicylic acid, phenyl ester
Seesorb K 201
salol
EINECS 204-259-2
MFCD00002213
2-hydroxybenzoic acid phenyl ester
Phenyl salicylate
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
306.6±0.0 °C at 760 mmHg
[ Melting Point ]:
41-43 °C(lit.)
[ Molecular Formula ]:
C13H10O3
[ Molecular Weight ]:
214.217
[ Flash Point ]:
137.3±13.2 °C
[ Exact Mass ]:
214.062988
[ PSA ]:
46.53000
[ LogP ]:
3.55
[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C
[ Index of Refraction ]:
1.615
[ Storage condition ]:
room temp
[ Stability ]:
Light sensitive. Incompatible with strong oxidants. Flammable.
[ Water Solubility ]:
dioxane: 0.1 g/mL, clear, colorless
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- VO6125000
- CHEMICAL NAME :
- Salicylic acid, phenyl ester
- CAS REGISTRY NUMBER :
- 118-55-8
- BEILSTEIN REFERENCE NO. :
- 0393969
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 11
- MOLECULAR FORMULA :
- C13-H10-O3
- MOLECULAR WEIGHT :
- 214.23
- WISWESSER LINE NOTATION :
- QR BVOR
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 14,837,1976
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 6,149,1954
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 3 gm/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Nutritional and Gross Metabolic - body temperature decrease
- REFERENCE :
- RMSRA6 Revue Medicale de la Suisse Romande. (Societe Medicale de La Suisse Romande, 2 rue Bellefontaine, 1003 Lausanne, Switzerland) V.1- 1881- Volume(issue)/page/year: 15,561,1895 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 600 mg/kg
- SEX/DURATION :
- female 7-12 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)
- REFERENCE :
- OCMJAJ Osaka City Medical Journal. (Osaka City Medical Center, 1-4-54, Asahi-machi, Abeno-ku, Osaka 545, Japan) V.1- 1954- Volume(issue)/page/year: 12,23,1966
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 1200 mg/kg
- SEX/DURATION :
- female 7-9 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- REFERENCE :
- OCMJAJ Osaka City Medical Journal. (Osaka City Medical Center, 1-4-54, Asahi-machi, Abeno-ku, Osaka 545, Japan) V.1- 1954- Volume(issue)/page/year: 12,23,1966
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 600 mg/kg
- SEX/DURATION :
- female 7-9 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetal death
- REFERENCE :
- OCMJAJ Osaka City Medical Journal. (Osaka City Medical Center, 1-4-54, Asahi-machi, Abeno-ku, Osaka 545, Japan) V.1- 1954- Volume(issue)/page/year: 12,23,1966 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80479 No. of Facilities: 241 (estimated) No. of Industries: 3 No. of Occupations: 8 No. of Employees: 2943 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80479 No. of Facilities: 471 (estimated) No. of Industries: 4 No. of Occupations: 11 No. of Employees: 5712 (estimated) No. of Female Employees: 2297 (estimated)
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S26-S36-S24/25
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
2
[ RTECS ]:
VO6125000
[ HS Code ]:
2918230000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2918230000
[ Summary ]:
2918230000 other esters of salicylic acid and their salts VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%
Articles
Acta Odontol. Scand. 52(3) , 150-6, (1994)
Unstimulated saliva was collected from orthodontic patients and subjected to combined gas-chromatography and gas-chromatography/mass-spectrometry analyses. Saliva was collected before insertion of rem...
Toxicol. Lett. 7(3) , 211-5, (1981)
The in vitro carcinogenic activities of 3-(N-salicyloyl)amino-1,2,4-triazole (SAT) and its two components, 3-amino-1,2,4-triazole and phenyl salicylate were examined in a transformation assay with cry...
Food Chem. Toxicol. 45 Suppl 1 , S472-6, (2007)
A toxicologic and dermatologic review of phenyl salicylate when used as a fragrance ingredient is presented.