Benzyl salicylate

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Names

[ CAS No. ]:
118-58-1

[ Name ]:
Benzyl salicylate

[Synonym ]:
benzyl 2-hydroxybenzoate
Salicylic Acid Benzyl Ester
Benzoic acid, 2-hydroxy-, phenylmethyl ester
2-Hydroxybenzoic Acid Benzyl Ester
2-Hydroxybenzoic acid, phenylmethyl ester
2-(HO)C6H4CO2CH2C6H5
Benzyl salicylate
Salicylic acid, benzyl ester
2-Hydroxybenzoic acid phenylmethyl ester
Benzyl o-hydroxybenzoate
phenylmethyl 2-hydroxybenzoate
EINECS 204-262-9
Salicyclic acid benzyl ester
MFCD00020034

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
320.0±0.0 °C at 760 mmHg

[ Melting Point ]:
18-20 °C

[ Molecular Formula ]:
C₁₄H₁₂O₃

[ Molecular Weight ]:
228.243

[ Flash Point ]:
146.4±13.7 °C

[ Exact Mass ]:
228.078644

[ PSA ]:
46.53000

[ LogP ]:
4.01

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.607

[ Water Solubility ]:
Slightly soluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VO1750000

CHEMICAL NAME :: Salicylic acid, benzyl ester

CAS REGISTRY NUMBER :: 118-58-1

BEILSTEIN REFERENCE NO. :: 2115365

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C14-H12-O3

MOLECULAR WEIGHT :: 228.26

WISWESSER LINE NOTATION :: QR BVO1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2227 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 11,1029,1973 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82924 No. of Facilities: 71 (estimated) No. of Industries: 4 No. of Occupations: 25 No. of Employees: 6137 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82924 No. of Facilities: 5081 (estimated) No. of Industries: 20 No. of Occupations: 46 No. of Employees: 74153 (estimated) No. of Female Employees: 42575 (estimated)

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H317-H319-H371

[ Precautionary Statements ]:
P260-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
VO1750000

[ HS Code ]:
2918230000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Benzyl bromide
Salicylic acid
Benzyl alcohol
Ethyl salicylate
Benzyl chloride
N,N-diisopropylethylamine hydrochloride
Benzyl 2-(benzyloxy)benzoate
Isopentyl 2-hydroxybenzoate
Methyl salicylate
Sodium Salicylate

DownStream

Glycine,N-(2-hydroxybenzoyl)-
Methyl 1-((2-Benzyloxycarbonxyl)phenyl)-2,3,4-tri-O-acetyl--D-glucopyranuronate
Methyl 1-[[2-N-(5-Nitrothiazolyl)carboxamido]phenyl]-2,3,4- tri-O-acetyl--D-glucopyranuronate
Methyl 1-(2-Carboxyphenyl)-2,3,4-tri-O-acetyl-β-D-glucopyranuronate
Benzoic acid,2-[[[trans-4-[[(aminoiminomethyl)amino]methyl]cyclohexyl]carbonyl]oxy]-,phenylmethyl ester, monohydrochloride (9CI)
2-[2-(4-chlorophenoxy)-2-methylpropanoyl]oxybenzoic acid
benzyl 2-acetyloxybenzoate

Customs

[ HS Code ]: 2918230000

[ Summary ]:
2918230000 other esters of salicylic acid and their salts VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Atmospheric pressure gas chromatography-time-of-flight-mass spectrometry (APGC-ToF-MS) for the determination of regulated and emerging contaminants in aqueous samples after stir bar sorptive extraction (SBSE).

Anal. Chim. Acta 851 , 1-13, (2014)

This work presents the development, optimization and validation of a multi-residue method for the simultaneous determination of 102 contaminants, including fragrances, UV filters, repellents, endocrin...

Optimization of an analytical methodology for the simultaneous determination of different classes of ultraviolet filters in cosmetics by pressurized liquid extraction-gas chromatography tandem mass spectrometry.

J. Chromatogr. A. 1405 , 12-22, (2015)

A methodology based on pressurized liquid extraction (PLE) followed by gas chromatography-tandem mass spectrometry (GC-MS/MS) has been developed for the simultaneous analysis of different classes of U...

Insulin sensitivity of liver glycogen synthase b into a conversion.

Mol. Cell Biochem. 25(1) , 47-59, (1979)

Liver glycogen synthase b phosphatase, chromatographically separable from phosphorylase a phosphatase, is decreased in 48-hour alloxan diabetic rats. The phosphatase activities are measured in an in v...

Perindopril benzyl salicylate
Benzyl 3-isothiocyanatophenyl ether
benzyl-dimethyl-(2-prop-2-enoyloxyethyl)azanium,prop-2-enamide,chloride
benzyl N-[1-phenyl-5-(pyrrol-1-yl)-1H-pyrazol-4-yl]carbamate
benzyl 5-acetoxymethyl-4-(2-chloroethyl)-3-methylpyrrole-2-carboxylate
benzyl 2-((2-methoxyphenyl)ethynyl)benzoate
O-[1-(2-chloro-6-fluorophenyl)ethyl]hydroxylamine
(S)-2-Thia-1,3,7-triazaspiro[4.5]decane 2,2-dioxide
2-Bromo-1-(4-methoxy-2-nitrophenyl)ethan-1-ol
2-[(4-Chloro-3-methylphenyl)methyl]propane-1,3-diol
6-(4-amino-1H-imidazol-1-yl)hexan-1-ol
3-(3-Hydroxypentan-3-yl)piperidine-3-carboxylic acid
3-(2,6-Dimethylphenyl)-3-methylbutan-1-amine
(1R,3R,5S)-3-(aminomethyl)-8-azabicyclo[3.2.1]octan-3-ol
1-[(Tert-butoxy)carbonyl]-4-ethynylpiperidine-4-carboxylicacid
1-[2-(Azetidin-3-yl)-2-fluoroacetyl]azetidine-2-carboxamide

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