5-Iodosalicylic acid

Names

[ CAS No. ]:
119-30-2

[ Name ]:
5-Iodosalicylic acid

[Synonym ]:
EINECS 204-313-5
5-Iodosalicylic acid
Benzoic acid, 2-hydroxy-5-iodo-
2-Hydroxy-5-iodobenzoic acid
MFCD00002458

Chemical & Physical Properties

[ Density]:
2.2±0.1 g/cm3

[ Boiling Point ]:
371.4±37.0 °C at 760 mmHg

[ Melting Point ]:
189-191 °C(lit.)

[ Molecular Formula ]:
C₇H₅IO₃

[ Molecular Weight ]:
264.017

[ Flash Point ]:
178.4±26.5 °C

[ Exact Mass ]:
263.928314

[ PSA ]:
57.53000

[ LogP ]:
3.67

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.712

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VO4200000

CHEMICAL NAME :: Salicylic acid, 5-iodo-

CAS REGISTRY NUMBER :: 119-30-2

BEILSTEIN REFERENCE NO. :: 2090443

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C7-H5-I-O3

MOLECULAR WEIGHT :: 264.02

WISWESSER LINE NOTATION :: QVR BQ EI

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 5,341,1953

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
VO4200000

[ HS Code ]:
29182990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Salicylic acid
2,5-DIIODOBENZOIC ACID
3-carboxylato-4-hydroxybenzenediazonium
5-Aminosalicylic Acid
Methyl 2-hydroxy-5-iodobenzoate
Methyl salicylate
Water
molecular iodine
Sodium Salicylate
Hydrogen iodide

DownStream

Gentisic acid
Methyl 2-hydroxy-5-iodobenzoate
Ethyl 2,5-dihydroxybenzoate
2-(Benzyloxy)-5-iodobenzoic acid
methyl 5-acetyloxy-2-iodobenzoate
Hydroquinone
Carbon dioxide
4-Iodophenol
5-Iodo-2-methoxybenzoic acid
2,4,6-Triiodophenol

Customs

[ HS Code ]: 2918290000

[ Summary ]:
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

Articles

Iodination of salicylic acid improves its binding to transthyretin.

Biochim. Biophys. Acta 1784(3) , 512-7, (2008)

Transthyretin (TTR) is a plasma homotetrameric protein associated with senile systemic amyloidosis and familial amyloidotic polyneuropathy. In theses cases, TTR dissociation and misfolding induces the...

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sodium salt of 5-iodosalicylic acid
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