LY-255582

Suppliers

Names

[ CAS No. ]:
119193-09-8

[ Name ]:
LY-255582

[Synonym ]:
(+)-1-[(3S)-3-Hydroxy-3-cyclohexylpropyl]-(3R,4R)-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine
(+)-1-(3(S)-3-hydroxy-3-cyclohexylpropyl)-3(R),4(R)-dimethyl-4-(3-hydroxyphenyl)piperidine

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₃₅NO₂

[ Molecular Weight ]:
345.51900

[ Exact Mass ]:
345.26700

[ PSA ]:
43.70000

[ LogP ]:
4.26090

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Activation of mesolimbic dopamine neurons during novel and daily limited access to palatable food is blocked by the opioid antagonist LY255582.

Am. J. Physiol. Regul. Integr. Comp. Physiol. 295(2) , R463-71, (2008)

An analog of the trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine series (LY255582) exhibits high in vitro binding affinity and antagonist potency for the mu-, delta-, and kappa-opioid receptors. In v...