LY-255582

Modify Date: 2024-01-12 10:08:42

LY-255582 structure	Common Name	LY-255582
	CAS Number	119193-09-8	Molecular Weight	345.51900
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₂H₃₅NO₂	Melting Point	N/A
	MSDS	USA	Flash Point	N/A

Use of LY-255582

LY255582 is a pan-opioid antagonist and has high affinity for mu, delta, and kappa receptors (Ki: 0.4 nM, 5.2, 2.0 nM respectively). LY255582 can decrease food intake and body weight. LY255582 can be used for the research of obesity[1][2][3][4].

Name	ly 255582
Synonym	More Synonyms

Description	LY255582 is a pan-opioid antagonist and has high affinity for mu, delta, and kappa receptors (Ki: 0.4 nM, 5.2, 2.0 nM respectively). LY255582 can decrease food intake and body weight. LY255582 can be used for the research of obesity[1][2][3][4].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Research Areas >> Metabolic Disease Signaling Pathways >> Neuronal Signaling >> Opioid Receptor
Target	μ Opioid Receptor/MOR:0.4 nM (Ki) δ Opioid Receptor/DOR:5.2 nM (Ki) κ Opioid Receptor/KOR:2.0 nM (Ki)
In Vitro	LY255582 (40 μM, 24-72 h) 抑制 Huh7 和 MHCC-97H 细胞活力[5]。
In Vivo	LY255582 (100 μg，i.c.v.) 减少大鼠的食物摄入量[1]。 LY255582 (15 mg/kg，皮下注射，每日一次) 减少喂食的肥胖 Zucker 大鼠的食物摄入量和体重增加[4]。 Animal Model: STZ-induced diabetic mice[1] Dosage: 100, 10 and 1 μg Administration: i.c.v. Result: Decreased food at 100, 10 and 1 μg by 76, 62 and 29%.
References	[1]. Levine AS, et al. Central administration of the opioid antagonist, LY255582, decreases short- and long-term food intake in rats. Brain Res. 1991 Dec 6;566(1-2):193-7. [2]. Need AB, et al. In vivo rat brain opioid receptor binding of LY255582 assessed with a novel method using LC/MS/MS and the administration of three tracers simultaneously. Life Sci. 2007 Oct 13;81(17-18):1389-96. [3]. S.L. Gackenheimer, et al. Localization of opioid receptor antagonist [3H]-LY255582 binding sites in mouse brain: Comparison with the distribution of mu, delta and kappa binding sites. Neuropeptides. 2005. 39 (6), 559-567. [4]. Shaw WN, et al. Long-term treatment of obese Zucker rats with LY255582 and other appetite suppressants. Pharmacol Biochem Behav. 1993 Nov;46(3):653-9. [5]. Chen DT, et al. The mu-opioid receptor is a molecular marker for poor prognosis in hepatocellular carcinoma and represents a potential therapeutic target. Br J Anaesth. 2019 Jun;122(6):e157-e167.

Molecular Formula	C₂₂H₃₅NO₂
Molecular Weight	345.51900
Exact Mass	345.26700
PSA	43.70000
LogP	4.26090

RIDADR	NONH for all modes of transport

(3R,4R)-3,4-dim...

CAS#:145678-86-0

LY-255582

CAS#:119193-09-8

Literature: Werner, John A.; Cerbone, Louis R.; Frank, Scott A.; Ward, Jeffrey A.; Labib, Parviz; Tharp-Taylor, Roger W.; Ryan Journal of Organic Chemistry, 1996 , vol. 61, # 2 p. 587 - 597

Precursor 1
CAS#:145678-86-0 (3R,4R)-3,4-dim...
DownStream 0

Activation of mesolimbic dopamine neurons during novel and daily limited access to palatable food is blocked by the opioid antagonist LY255582.

Am. J. Physiol. Regul. Integr. Comp. Physiol. 295(2) , R463-71, (2008)

An analog of the trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine series (LY255582) exhibits high in vitro binding affinity and antagonist potency for the mu-, delta-, and kappa-opioid receptors. In v...

(+)-1-[(3S)-3-Hydroxy-3-cyclohexylpropyl]-(3R,4R)-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine

(+)-1-(3(S)-3-hydroxy-3-cyclohexylpropyl)-3(R),4(R)-dimethyl-4-(3-hydroxyphenyl)piperidine

LY-255582

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