Ethylparaben
Suppliers
Names
[ CAS No. ]:
120-47-8
[ Name ]:
Ethylparaben
[Synonym ]:
Sobrol A
Easeptol
4-Hydroxybenzoic acid, ethyl ester
Ethyl parasept
Benzoic acid, 4-hydroxy-, ethyl ester
ethyl p-hydroxybenzoate
para-hydroxybenzoic acid ethyl ester
nipazina
Ethyl chemosept
4-hydroxybenzoic ethyl ester
nipagina
Mycocten
Solbrol A
napagina
ETHYL PARABEN
ethyl para-hydroxybenzoate
Ethyl 4-hydroxybenzoate
solbrola
Keloform
4-hydroxybenzoic acid ethyl ester
EINECS 204-399-4
4-hydrodxybenzoic acid ethylester
Nipagina A
4-Hydroxy-Benzoicaciethylester
Ethyl p-oxybenzoate
Ethylparaben
MFCD00002353
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Boiling Point ]:
297.5±0.0 °C at 760 mmHg
[ Melting Point ]:
114-117 °C(lit.)
[ Molecular Formula ]:
C9H10O3
[ Molecular Weight ]:
166.174
[ Flash Point ]:
120.3±12.6 °C
[ Exact Mass ]:
166.062988
[ PSA ]:
46.53000
[ LogP ]:
2.40
[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C
[ Index of Refraction ]:
1.539
[ Stability ]:
Stable. Combustible. Incompatible with strong oxidizing agents, strong bases.
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DH2190000
- CHEMICAL NAME :
- Benzoic acid, p-hydroxy-, ethyl ester
- CAS REGISTRY NUMBER :
- 120-47-8
- BEILSTEIN REFERENCE NO. :
- 1101972
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 15
- MOLECULAR FORMULA :
- C9-H10-O3
- MOLECULAR WEIGHT :
- 166.19
- WISWESSER LINE NOTATION :
- QR DVO2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 520 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 504 gm/kg/12W-C
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 45600 mg/kg
- SEX/DURATION :
- female 8-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
MUTATION DATA
- TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 440 mg/L
- REFERENCE :
- GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971- Volume(issue)/page/year: 27,95,1981 *** REVIEWS *** TOXICOLOGY REVIEW ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 4,575,1954 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82869 No. of Facilities: 103 (estimated) No. of Industries: 3 No. of Occupations: 7 No. of Employees: 3241 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82869 No. of Facilities: 307 (estimated) No. of Industries: 6 No. of Occupations: 7 No. of Employees: 4591 (estimated) No. of Female Employees: 1145 (estimated)
Safety Information
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi: Irritant;
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S26-S36-S24/25
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
1
[ RTECS ]:
DH2190000
[ HS Code ]:
2918290000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2918290000
[ Summary ]:
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%
Articles
Talanta 143 , 254-62, (2015)
Parabens are widely used in dairy products, such as in cosmetics and personal care products. Thus, in this work a multi-syringe chromatographic (MSC) system is proposed for the first time for the dete...
Int. J. Food Microbiol. 214 , 145-50, (2015)
Alicyclobacillus acidoterrestris can survive the pasteurization process, multiply in pasteurized juices and produce guaiacol which causes medicinal or antiseptic off-flavors. Chemical preservatives ha...
Bioorg. Med. Chem. 17 , 896-904, (2009)
This paper reports a QSAR study for predicting the complexation of a large and heterogeneous variety of substances (233 organic compounds) with beta-cyclodextrins (beta-CDs). Several different theoret...