Ethylparaben

Modify Date: 2024-01-01 17:45:37

Ethylparaben Structure
Ethylparaben structure
Common Name Ethylparaben
CAS Number 120-47-8 Molecular Weight 166.174
Density 1.2±0.1 g/cm3 Boiling Point 297.5±0.0 °C at 760 mmHg
Molecular Formula C9H10O3 Melting Point 114-117 °C(lit.)
MSDS Chinese USA Flash Point 120.3±12.6 °C

 Use of Ethylparaben


Ethylparaben is the ethyl ester of p-hydroxybenzoic acid, used as an antifungal preservative. and food additive

 Names

Name Ethylparaben
Synonym More Synonyms

 Ethylparaben Biological Activity

Description Ethylparaben is the ethyl ester of p-hydroxybenzoic acid, used as an antifungal preservative. and food additive
Related Catalog

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 297.5±0.0 °C at 760 mmHg
Melting Point 114-117 °C(lit.)
Molecular Formula C9H10O3
Molecular Weight 166.174
Flash Point 120.3±12.6 °C
Exact Mass 166.062988
PSA 46.53000
LogP 2.40
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.539
Stability Stable. Combustible. Incompatible with strong oxidizing agents, strong bases.

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DH2190000
CHEMICAL NAME :
Benzoic acid, p-hydroxy-, ethyl ester
CAS REGISTRY NUMBER :
120-47-8
BEILSTEIN REFERENCE NO. :
1101972
LAST UPDATED :
199701
DATA ITEMS CITED :
15
MOLECULAR FORMULA :
C9-H10-O3
MOLECULAR WEIGHT :
166.19
WISWESSER LINE NOTATION :
QR DVO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
520 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
504 gm/kg/12W-C
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
45600 mg/kg
SEX/DURATION :
female 8-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
440 mg/L
REFERENCE :
GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971- Volume(issue)/page/year: 27,95,1981 *** REVIEWS *** TOXICOLOGY REVIEW ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 4,575,1954 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82869 No. of Facilities: 103 (estimated) No. of Industries: 3 No. of Occupations: 7 No. of Employees: 3241 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82869 No. of Facilities: 307 (estimated) No. of Industries: 6 No. of Occupations: 7 No. of Employees: 4591 (estimated) No. of Female Employees: 1145 (estimated)

 Safety Information

Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36-S24/25
RIDADR NONH for all modes of transport
WGK Germany 1
RTECS DH2190000
HS Code 2918290000

 Synthetic Route

 Customs

HS Code 2918290000
Summary HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

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 Synonyms

Sobrol A
Easeptol
4-Hydroxybenzoic acid, ethyl ester
Ethyl parasept
Benzoic acid, 4-hydroxy-, ethyl ester
ethyl p-hydroxybenzoate
para-hydroxybenzoic acid ethyl ester
nipazina
Ethyl chemosept
4-hydroxybenzoic ethyl ester
nipagina
Mycocten
Solbrol A
napagina
ETHYL PARABEN
ethyl para-hydroxybenzoate
Ethyl 4-hydroxybenzoate
solbrola
Keloform
4-hydroxybenzoic acid ethyl ester
EINECS 204-399-4
4-hydrodxybenzoic acid ethylester
Nipagina A
4-Hydroxy-Benzoicaciethylester
Ethyl p-oxybenzoate
Ethylparaben
MFCD00002353
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